Lysine HCl
AKA “L-Lysine hydrochloride, L-Lysine monohydrochloride, lysine hydrochloride, L-Lysine, monohydrochloride, L-(+)-Lysine Monohydrochloride, Lysine hcl, Lysine”
Synthetic
Ingredient Facts
Lysine hcl
AKA: L-Lysine hydrochloride, L-Lysine monohydrochloride, Lysine hydrochloride, L-Lysine, Monohydrochloride, L-(+)-Lysine Monohydrochloride
Synthetic · Hair Conditioning · EWG: 4
Synthetic
Skin Conditioner
Hair Care
Amino Acid
Synthetic
Clean
An amino acid that strengthens and moisturizes hair and skin, helping to improve texture and resilience for a smoother, healthier appearance.
Effective at 0.35%
Formula
C6H15ClN2O2
Mol. Weight
182.65
CAS #
657-27-2, 10098-89-2, 22834-80-6
Form
Powder
State
Solid; [Merck Index] White powder; [Sigma-Aldrich MSDS]
See origin →
Functions
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
L-lysine was identified as an essential amino acid in the early 20th century. Its use in skincare is a modern application developed to support collagen formation and skin barrier function.
Skin Types
●all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe
Pregnancy
Yes
CIR Safety Findings
Not Phototoxic
medical-approval
all-shades-safe
Concentration Guide
2e-05%
0.7%
0%100%
Effective Range
CIR reported use: 0.0009-0.001 | 0.00002-0.7 | 0.00003-0.6
Regulatory Agencies
Lauroyl Lysine
European Commission
EU Cosmetic Ingredient Database (CosIng)
Lysine HCl
European Commission
EU Cosmetic Ingredient Database (CosIng)
Safety and efficacy of l-histidine monohydrochloride monohydrate produced using Corynebacterium glutamicum KCCM 80179 for all animal species.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, de Lourdes Bastos M, Christensen H et al.
EFSA journal. European Food Safety Authority, 2019
Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicum KCC
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, Bastos ML, Christensen H et al.
EFSA journal. European Food Safety Authority, 2020
Lauroyl Lysine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Lysine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Sodium Dilauramidoglutamide Lysine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Novel design of pyrrolidonecarboxylic acid and sodium dilauramidoglutamide lysine complex for targeted drug delivery to human stratum corneum.
Fujii MY, Manabe H, Ogura T
International journal of pharmaceutics, 2025
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR