Mannose
AKA “(2S, 3S, 4R, 5R)-2, 3, 4, 5, 6-pentahydroxyhexanal, Demannose, PHA4727WTP, CERC-802, GlyTouCan:G95531HX, RefChem:1083138, G95531HX, 3458-28-4, aldehydo-D-mannose, 31103-86-3
Humectant
Ingredient Facts
Mannose
AKA: (2S, 3S, 4R, 5R)-2, 3, 4, 5, 6-pentahydroxyhexanal, Demannose, PHA4727WTP, CERC-802, GlyTouCan:G95531HX, RefChem:1083138, G95531HX, 3458-28-4, Aldehydo-D-mannose, 31103-86-3
Humectant · Humectant · EWG: 1
Synthetic
Humectant
Clean
Aldehydo-D-mannose is the D-enantiomer of aldehydo-mannose. It is a D-mannose and an aldehydo-mannose. It is an enantiomer of an aldehydo-L-mannose.
Effective at 4.7%
Formula
C6H12O6
Mol. Weight
180.16
CAS #
3458-28-4
Form
Powder
State
White hygroscopic powder; [Alfa Aesar MSDS]
See origin →
Functions
Humectant
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Locks In Moisture
Traditional Use
A simple sugar identified in the late 19th century and found naturally in various plants and fruits. Adopted in modern skincare formulations in recent decades as a humectant and skin hydration agent, though no significant historical cosmetic use exists.
Skin Types
all-skin-types
Best For
Dehydration
Pregnancy & Breastfeeding Safe
Yes
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
0.0005%
9.4%
0%13%
Effective Range
CIR reported use: 0.0005-9.4 | 0.3-0.5
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR