Methyl Glycyrrhizate
AKA “GAMME, Glycyrrhizic acid methyl ester, RefChem:144015, DTXCID401506590, UNII-A4TET7070S, (2S, 14bS)-11-methoxycarbonyl-4, 14b-heptamethyl-14-oxo-2”
Synthetic
vote to see if the hive agrees
Ingredient Facts
Methyl glycyrrhizate
AKA: GAMME, Glycyrrhizic acid methyl ester, RefChem:144015, DTXCID401506590, UNII-A4TET7070S, (2S, 14bS)-11-methoxycarbonyl-4, 14b-heptamethyl-14-oxo-2
Synthetic · Soothing | Skin Conditioning | Antioxidant · EWG: 4
Plant-Derived
Antioxidant
Soothing
Skin Conditioner
Synthetic
Clean
Derived from licorice root, this natural-origin fragrance ingredient adds a subtle, warm scent to the formula while complementing the product's skincare benefits.
Formula
C43H62O16-2
Mol. Weight
834.90
CAS #
104191-95-9
Form
Powder
Plant-Derived
Synthetic. Derived from glycyrrhizin, the main active compound extracted from licorice root (Glycyrrhiza glabra). Produced through esterification of glycyrrhizin with methanol to create the methyl ester derivative.
Function
Soothing | Skin Conditioning | Antioxidant
Benefits
Brightens uneven skin tone
Evens pigmentation
Quells irritation
Traditional Use
Derived from licorice (Glycyrrhiza glabra), which has been used in Traditional Chinese Medicine and Ayurveda for over 2,000 years for skin soothing and anti-inflammatory benefits. The methylated form was developed to improve stability in modern cosmetic formulations.
Skin Types
all-skin-types
Best For
Target
Irritation
Melanin-Rich Skin
Suitable
Pregnancy Safe
Yes
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR