Methyl Glycyrrhizate
AKA “104191-95-9, GAMME, Glycyrrhizic acid methyl ester, A4TET7070S, DTXSID801021582, RefChem:144015, DTXCID401506590, UNII-A4TET7070S, (2S, 3S, 4S, 5R, 6R)-6-[(2S, 3R, 5S, 6S)-2-[[(3S, 4aR, 6aR, 6bS, 8aS, 11S, 12aR, 14aR, 14bS)-11-methoxycarbonyl-4, 4, 6a, 6b, 8a, 11, 14b-heptamethyl-14-oxo-2, 3, 4a, 5, 6, 7, 8, 9, 10, 12, 12a, 14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxylato-4, 5-dihydroxyoxan-3-yl]oxy-3, 5-trihydroxyoxane-2-carboxylate
Ingredient
Ingredient Facts
Methyl glycyrrhizate
AKA: 104191-95-9, GAMME, Glycyrrhizic acid methyl ester, A4TET7070S, DTXSID801021582, RefChem:144015, DTXCID401506590, UNII-A4TET7070S, (2S, 3S, 4S, 5R, 6R)-6-[(2S, 3R, 5S, 6S)-2-[[(3S, 4aR, 6aR, 6bS, 8aS, 11S, 12aR, 14aR, 14bS)-11-methoxycarbonyl-4, 4, 6a, 6b, 8a, 11, 14b-heptamethyl-14-oxo-2, 3, 4a, 5, 6, 7, 8, 9, 10, 12, 12a, 14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxylato-4, 5-dihydroxyoxan-3-yl]oxy-3, 5-trihydroxyoxane-2-carboxylate
Ingredient · Fragrance · EWG: 4
Synthetic
Fragrance
Not Clean
alpha-d-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-o-beta-d-glucopyranuronosyl-, methyl ester; Glycyrrhizic acid methyl ester
Formula
C43H62O16-2
Mol. Weight
834.90
CAS #
104191-95-9
Form
Powder
See origin →
Functions
Fragrance
Added for scent. Can be natural or synthetic. Common irritant and allergen — one of the top reasons people react to products.
Brightens uneven skin tone
Evens pigmentation
Quells irritation
Traditional Use
Derived from licorice (Glycyrrhiza glabra), which has been used in Traditional Chinese Medicine and Ayurveda for over 2,000 years for skin soothing and anti-inflammatory benefits. The methylated form was developed to improve stability in modern cosmetic formulations.
Skin Types
all-skin-types
Best For
Irritation
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not an Irritant
medical-approval
all-shades-safe
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR