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Mixed Isopropanolamine
AKA “1-Aminopropan-2-ol, 1-AMINO-2-PROPANOL, Isopropanolamine, Threamine, Monoisopropanolamine”
Ingredient
Ingredient Facts
Mixed isopropanolamine
AKA: 1-Aminopropan-2-ol, 1-AMINO-2-PROPANOL, Threamine, Monoisopropanolamine
Ingredient · Buffering · EWG: 4
Synthetic
Not Clean
Mixed Isopropanolamines is a blend of Isopropanolamine, Diisopropanolamine and Triisopropanolamine
Formula
C3H9NO
Mol. Weight
75.11
CAS #
78-96-6
Form
Liquid
See origin →
Functions
Buffering
Stabilizes pH
UV Protection
Traditional Use
Developed in the 20th century as a pH buffer and emulsifier in cosmetics. Created to stabilize formulations and adjust acidity, particularly in cleansing and conditioning products.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
EWG
4
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU✔ permitted
JAPAN✔ permitted
CANADA✔ permitted
Extended Re-review Summary: Safety Assessment of Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed Isopropanolamines
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
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Final Report on the Safety Assessment of Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed Isopropanolamine
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Isopropanolamine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Triisopropanolamine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diisopropanolamine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Isopropanolamine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Mixed Isopropanolamine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Mixed Isopropanolamines
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Triisopropanolamine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
β-elemene Isopropanolamine Derivative LXX-8250 Induces Apoptosis Through Impairing Autophagic Flux via PFKFB4 Repression in Melanoma Cells.
Jalal S, Zhang T, Deng J, Wang J, Xu T et al.
Frontiers in pharmacology, 2022
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Pharmacokinetics and bioavailability of diisopropanolamine (DIPA) in rats following intravenous or dermal application.
Saghir SA, Frantz SW, Spence MW, Nolan RJ, Lowe ER et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2007
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR