Morpholine
AKA “110-91-8, 1-Oxa-4-azacyclohexane, Diethylene oximide, Tetrahydro-1, 4-oxazine, Diethylenimide oxide, Diethyleneimide oxide, Diethylene imidoxide, Drewamine, Tetrahydro-2H-1
Ingredient
Ingredient Facts
Morpholine
AKA: 110-91-8, 1-Oxa-4-azacyclohexane, Diethylene oximide, Tetrahydro-1, 4-oxazine, Diethylenimide oxide, Diethyleneimide oxide, Diethylene imidoxide, Drewamine, Tetrahydro-2H-1
Ingredient · Buffering · EWG: 7
Synthetic
Not Clean
Morpholine is an organic heteromonocyclic compound whose six-membered ring contains four carbon atoms and one nitrogen atom and one oxygen atom that lies opposite to each other; the parent compound of the morpholine family. It is a saturated organic heteromonocyclic parent and a member of morpholines. It is a conjugate base of a morpholinium.
Solubility Soluble (NTP, 1992)
Formula
C4H9NO
Mol. Weight
87.12
CAS #
110-91-8
Form
Liquid
State
Morpholine appears as a colorless liquid with a fishlike odor. Flash point 100 °F. Corrosive to tissue. Less dense than water and soluble in water. Vapors heavier than air. Used to make other chemical
See origin →
Functions
Buffering
Anti-Inflammatory
Antimicrobial
Fights Acne
Maintains optimal pH
Traditional Use
Developed in the early 20th century as an organic compound in industrial chemistry. Adopted in cosmetics as a pH adjuster and buffering agent, particularly in formulations requiring stable acidity control.
Skin Types
all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
EWG
7
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USApermitted
EUpermitted
JAPANpermitted
CANADApermitted
🧂Conflict of interest.
Final Report on the Safety Assessment of Hydroxybenzomorpholine
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Isostearamidopropyl Morpholine Lactate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Morpholine
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Hydroxybenzomorpholine
European Commission
EU Cosmetic Ingredient Database (CosIng)
Isostearamidopropyl Morpholine Lactate
European Commission
EU Cosmetic Ingredient Database (CosIng)
Hydroxybenzomorpholine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Isostearamidopropyl Morpholine Lactate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Morpholine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Isostearamidopropyl Morpholine Lactate.
Fiume MM
International journal of toxicology, 2017
Isostearamidopropyl Morpholine Lactate.
Fiume MM
International journal of toxicology, 2017
Morpholine and its salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Verified Jun 2026 · 🧪 = conflict
Data: PubChem · CosIng · EWG · CIR