undefined 1
N,N-Bis(Hydroxyethyl)-p-Phenylenediamine Sulfate
AKA “Hydroxyethyl -p-Phenylenediamine Sulfate”
Ingredient
Ingredient Facts
N,n-bis (Hydroxyethyl) -p-phenylenediamine sulfate
AKA: Hydroxyethyl -p-Phenylenediamine Sulfate
Ingredient · Cleansing · EWG: 4
Synthetic
Cleanser
Not Clean
N,N-Bis(Hydroxyethyl)-p-Phenylenediamine Sulfate is a cosmetic ingredient. Assessed as safe by the CIR.
Formula
C10H18N2O6S
Mol. Weight
294.33
CAS #
54381-16-7
Form
Powder
See origin →
Functions
Surfactant
Makes oil and water mix so dirt, makeup, and sunscreen can actually be washed away. The reason your face wash foams.
Cleansing
Makes oil and water mix so dirt, makeup, and sunscreen can actually be washed away. The reason your face wash foams.
Hair Dyeing
Moisturizing
Wound Healing
Improves Elasticity
Colors hair
Traditional Use
A synthetic chemical used in oxidative hair dye formulations, developed in the mid-20th century. Created as an intermediate to facilitate permanent hair color development in modern cosmetics.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
Allergen Warning
⚠️ PPD (Hair Dye)
EWG
4
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
CANADA✔ permitted
Regulatory Agencies
Safety Assessment of Hydroxyethyl Urea as Used in Cosmetics.
Akinsulie A, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2024
→
Safety Assessment of Hydroxypropyl Bis(N-Hydroxyethyl-p-Phenylenediamine) HCl as Used in Cosmetics.
Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2016
→
Safety Assessment of 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate as Used in Cosmetics.
Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2022
→
Evaluation of the teratological and dominant lethal potential of N,N-bis-(2-hydroxyethyl)-p-phenylenediamine sulphate in a 6-month feeding study in ra
Burnett CM, Re TA, Loehr RF, Rodriguez SC, Corbett JF
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1986
→
Final Report on the Safety Assessment of 2-Methyl-5-Hydroxyethylaminophenol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Hydroxyethylcellulose, Hydroxypropylcellulose, Methylcellulose, Hydroxypropyl Methylcellulose, and Cellulose Gum
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of N,N-Bis(Hydroxyethyl)-p-Phenylenediamine Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Re-evaluation: N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate as Used in Cosemtics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of 2-Amino-4-Hydroxyethylaminoanisole and 2-Amino-4-Hydroxyethylaminoanisole Sulfate as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Hydroxyethyl Urea As Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Hydroxyethyl-3,4-Methylenedioxyaniline HCl as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Hydroxypropyl Bis(N-Hydroxyethyl-p-Phenylenediamine) HCl as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
2-Amino-4-Hydroxyethylaminoanisole
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
2-Amino-4-Hydroxyethylaminoanisole Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
2-Methyl-5-Hydroxyethylaminophenol
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
3-Nitro-p-Hydroxyethylaminophenol
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Acrylates/Hydroxyethyl Acrylate/Lauryl Acrylate Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Acrylates/Hydroxyethyl Acrylate/Methoxyethyl Acrylate Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
AMP-Acrylates/C1-18 Alkyl Acrylate/C1-8 Alkyl Acrylamide/Hydroxyethylacrylate Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Bis-Hydroxyethyl Acrylate Poly(1,4-Butanediol)-9/TMHDI Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Butyl Acrylate/Hydroxyethyl Methacrylate Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
C12-22 Alkyl Acrylate/Hydroxyethylacrylate Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Carboxymethyl Hydroxyethylcellulose
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Cetyl Hydroxyethylcellulose
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Dimethyl Acrylamide/Hydroxyethyl Acrylate/Methoxyethyl Acrylate Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydrolyzed Corn Starch Hydroxyethyl Ether
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydroxyethyl Acrylate/Methoxyethyl Acrylate Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydroxyethyl Cyclodextrin
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydroxyethyl Ethylcellulose
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydroxyethyl Stearamide-MIPA
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydroxyethyl Urea
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydroxyethyl-3,4-Methylenedioxyaniline HCl
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydroxyethylcellulose
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydroxyethylcellulose/Phosphorylcholine Glycol Acrylate Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydroxypropyl Bis(N-Hydroxyethyl-p-Phenylenediamine) HCl
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Methyl Hydroxyethylcellulose
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Polyhydroxyethylmethacrylate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Polyperfluoroethoxymethoxy Difluorohydroxyethyl Ether
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
PPG-1 Hydroxyethyl Caprylamide
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
PPG-2 Hydroxyethyl Cocamide
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
PPG-2 Hydroxyethyl Coco/Isostearamide
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
PPG-3 Hydroxyethyl Soyamide
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
2-Amino-4-Hydroxyethylaminoanisole
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
2-Amino-4-Hydroxyethylaminoanisole Sulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
2-Methyl-5-Hydroxyethylaminophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
3-Nitro-p-Hydroxyethylaminophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Carboxymethyl Hydroxyethylcellulose
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Cetyl Hydroxyethylcellulose
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hydrolyzed Corn Starch Hydroxyethyl Ether
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hydroxyethyl Acrylate/Methoxyethyl Acrylate Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hydroxyethyl Ethylcellulose
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hydroxyethyl Urea
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hydroxyethyl-3,4-Methylenedioxyaniline HCl
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hydroxyethylcellulose
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hydroxypropyl Bis(N-Hydroxyethyl-p-Phenylenediamine) HCl
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Methyl Hydroxyethylcellulose
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
PPG-2 Hydroxyethyl Cocamide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
PPG-2 Hydroxyethyl Coco/Isostearamide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Toluidines, their isomers, salts and halogenated and sulfonated derivatives except 4-hydroxy-2-nitro-toluidine and hydroxyethyl-2-nitro-p-toluidine
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Biocompatible zinc oxide nanocrystals stabilized via hydroxyethyl cellulose for mitigation of diabetic complications.
Hussein J, El-Banna M, Razik TA, El-Naggar ME
International journal of biological macromolecules, 2018
→
2-Amino-4-hydroxyethylaminoanisole sulfate - a coupler causing contact allergy from use in hair dyes.
Madsen JT, Andersen KE
Contact dermatitis, 2016
→
2-Amino-4-hydroxyethylaminoanisole sulfate - a coupler causing contact allergy from use in hair dyes.
Madsen JT, Andersen KE
Contact dermatitis, 2016
→
Cytotoxicity study of homopolymers and copolymers of 2-hydroxyethyl methacrylate and some alkyl acrylates for potential use as temporary skin substitu
Prasitsilp M, Siriwittayakorn T, Molloy R, Suebsanit N, Siriwittayakorn P et al.
Journal of materials science. Materials in medicine, 2003
→
Safety Assessment of Hydroxyethyl-3,4-Methylenedioxyaniline HCl as Used in Cosmetics.
Scott LN, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2022
→
Allergy to 3-nitro-p-hydroxyethylaminophenol and 4-amino-3-nitrophenol in a hair dye.
Søsted H, Menné T
Contact dermatitis, 2005
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR