Octyldodecyl Oleate
AKA “2-Octyldodecyl oleate, 22801-45-2, MCA43PK7MH, 9-Octadecenoic acid, 2-octyldodecyl ester, Oleic acid, EINECS 245-228-3, octyldodecyl ester, DTXSID401010286, 9-Octadecenoic acid (9Z)-”
Emollient
Ingredient Facts
Octyldodecyl oleate
AKA: 2-Octyldodecyl oleate, 22801-45-2, MCA43PK7MH, 9-Octadecenoic acid, 2-octyldodecyl ester, Oleic acid, EINECS 245-228-3, Octyldodecyl ester, DTXSID401010286, 9-Octadecenoic acid (9Z)-
Emollient · Emollient · EWG: 1
Synthetic
Emollient
Skin Conditioner
Clean
2-Octyldodecyl 9-(Z)-octadecenoate
Effective at 44.05%
Formula
C38H74O2
Mol. Weight
563.00
CAS #
22801-45-2
Form
Liquid
See origin →
Functions
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Locks In Moisture
Traditional Use
Modern synthetic ester derived from oleic acid (found in olive oil and other natural sources), developed in the 20th century to provide emollient properties. Created to capture the skin-conditioning benefits of natural oils with improved stability and consistency.
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
0.1%
88.0%
0%100%
Effective Range
CIR reported use: 0.5-62 | 0.5-20 | 0.1-88
Regulatory Agencies
Final Report on the Safety Assessment of Oleic Acid, Lauric Acid, Palmitic Acid, Myristic Acid, and Stearic Acid
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Ricinus Communis (Castor) Seed Oil, Hydrogenated Castor Oil, Glyceryl Ricinoleate, Glyceryl Ricinoleate SE, Ricinoleic Acid, Potassium Ricinoleate, Sodium Rici
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Dilinoleic Acid/Butanediol Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
Isomerized Linoleic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
Octyldodecyl Oleate
European Commission
EU Cosmetic Ingredient Database (CosIng)
Oleic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
PEG-8 Dimethicone/Dimer Dilinoleic Acid Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
Ricinoleic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
Trilinoleic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
Dilinoleic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Dilinoleic Acid/Butanediol Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Isomerized Linoleic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Linoleic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Octyldodecyl Oleate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Oleic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Ricinoleic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Efficacy of an emollient containing diethylene glycol/dilinoleic acid copolymer for the treatment of dry skin and pruritus in patients with senile xer
Izumi R, Negi O, Suzuki T, Tominaga M, Kamo A et al.
Journal of cosmetic dermatology, 2017
Time-Dependent Differences in the Effects of Oleic Acid and Oleyl Alcohol on the Human Skin Barrier.
Kováčik A, Kopečná M, Hrdinová I, Opálka L, Boncheva Bettex M et al.
Molecular pharmaceutics, 2023
Linoleic Acid Induced Changes in SZ95 Sebocytes-Compariso...
Dóra Kovács, Emanuela Camera, Szilárd Póliska, Alessia Cavallo, Miriam Maiellaro, Katalin Dull + 4 more
Nutrients, 2023
Effect of a combination of medium chain triglycerides, linoleic acid, soy lecithin and vitamins A and E on wound healing in rats.
Magalhães MS, Fechine FV, Macedo RN, Monteiro DL, Oliveira CC et al.
Acta cirurgica brasileira, 2008
Resolved Psoriasis with Abundant Oleic Acid in Stratum Co...
Yasmin El Mahi, Alexis Varin, Mathieu Vetter, Ludivine Dal Zuffo, Loïc Mazzeo, Jean-Paul Pais De Barros + 3 more
The Journal of investigative dermatology, 2023
Resolved Psoriasis with Abundant Oleic Acid in Stratum Co...
Yasmin El Mahi, Alexis Varin, Mathieu Vetter, Ludivine Dal Zuffo, Loïc Mazzeo, Jean-Paul Pais De Barros + 3 more
The Journal of investigative dermatology, 2023
Differentiation of Malassezia species: selectivity of cremophor EL, castor oil and ricinoleic acid for M. furfur.
Mayser P, Haze P, Papavassilis C, Pickel M, Gruender K et al.
The British journal of dermatology, 1997
Differentiation of Malassezia species: selectivity of cremophor EL, castor oil and ricinoleic acid for M. furfur.
Mayser P, Haze P, Papavassilis C, Pickel M, Gruender K et al.
The British journal of dermatology, 1997
Differentiation of Malassezia species: selectivity of cremophor EL, castor oil and ricinoleic acid for M. furfur.
Mayser P, Haze P, Papavassilis C, Pickel M, Gruender K et al.
The British journal of dermatology, 1997
Fatty acid composition and productive traits of broiler fed diets containing conjugated linoleic acid.
Sirri F, Tallarico N, Meluzzi A, Franchini A
Poultry science, 2003
The Role of Linoleic Acid in Skin and Hair Health: A Review.
Xi Wang, Yan Jia, Huaming He
International journal of molecular sciences, 2024
The Role of Linoleic Acid in Skin and Hair Health: A Review.
Xi Wang, Yan Jia, Huaming He
International journal of molecular sciences, 2024
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR