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OXIDE
AKA “3, 6-Dihydro-2, 4-dimethyl-6-phenyl-2H-pyran, 68039-40-7, 2, 4-dimethyl-6-phenyl-3, 6-dihydro-2H-pyran, EINECS 268-256-8, 4, 6-Dimethyl-2-phenyl-1-oxacyclohex-3-ene, 2H-Pyran, 6-dihydro-2, 4-dimethyl-6-phenyl-, 5, 6-Dihydro-4, 6-dimethyl-2-phenyl-2H-pyran, DTXSID90867447, RefChem:484339, DTXCID20815633”
Ingredient
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Ingredient Facts
OXIDE
AKA: 3, 6-Dihydro-2, 4-dimethyl-6-phenyl-2H-pyran, 68039-40-7, 2, 4-dimethyl-6-phenyl-3, 6-dihydro-2H-pyran, EINECS 268-256-8, 4, 6-Dimethyl-2-phenyl-1-oxacyclohex-3-ene, 2H-Pyran, 6-dihydro-2, 4-dimethyl-6-phenyl-, 5, 6-Dihydro-4, 6-dimethyl-2-phenyl-2H-pyran, DTXSID90867447, RefChem:484339, DTXCID20815633
Ingredient · Perfuming
Synthetic
Fragrance
Not Clean
3,6-Dihydro-2,4-dimethyl-6-phenyl-2H-pyran
Mol. Weight
188.26
CAS #
68039-40-7
State
Solid
See origin →
Functions
Perfuming
Added for scent. Can be natural or synthetic. Common irritant and allergen — one of the top reasons people react to products.
Metal and metal oxide-based antiviral nanoparticles: Properties, mechanisms of action, and applications.
Alavi M, Kamarasu P, McClements DJ, Moore MD
Advances in colloid and interface science, 2022
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Green and eco-friendly biosynthesis of zinc oxide nanoparticles using Calendula officinalis flower extract: Wound healing potential and antioxidant ac
Aydin Acar C, Gencer MA, Pehlivanoglu S, Yesilot S, Donmez S
International wound journal, 2024
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Green and eco-friendly biosynthesis of zinc oxide nanoparticles using Calendula officinalis flower extract: Wound healing potential and antioxidant ac
Aydin Acar C, Gencer MA, Pehlivanoglu S, Yesilot S, Donmez S
International wound journal, 2024
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The toxicology of indium oxide.
Bomhard EM
Environmental toxicology and pharmacology, 2018
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Social Media Response to the Trimethylbenzoyl Diphenylphosphine Oxide Ban in Gel Nail Polish.
Chalupczak NV, Lipner SR
Journal of cutaneous medicine and surgery, 2025
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Amended Final Report of the Safety Assessment on Cocamidopropylamine Oxide
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Final Report on the Safety Assessment of Cocamidopropylamine Oxide
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International Journal of Toxicology
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Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide
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Final Report: Safety Assessment of Ammonia and Ammonium Hydroxide as Used in Cosmetics
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Safety Assessment of Alumina and Aluminum Hydroxide as Used in Cosmetics
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Safety Assessment of Hydrogen Peroxide as Used in Cosmetics
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Safety Assessment of Hydroxy Tetramethylpiperidine Oxide and Tris(Tetramethylhydroxypiperidinol)) Citrate as Used in Cosmetics
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International Journal of Toxicology
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Safety Assessment of Inorganic Hydroxides as Used in Cosmetics
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International Journal of Toxicology
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Safety Assessment of Tin (IV) Oxide as Used in Cosmetics
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International Journal of Toxicology
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Ammonium Hydroxide
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
C30-45 Alkyl Dimethicone/Polycyclohexene Oxide Crosspolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Calcium Hydroxide
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Cocamidopropylamine Oxide
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydrogen Peroxide
European Commission
EU Cosmetic Ingredient Database (CosIng)
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Iron Hydroxide
European Commission
EU Cosmetic Ingredient Database (CosIng)
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Lauramine Oxide
European Commission
EU Cosmetic Ingredient Database (CosIng)
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Magnesium Hydroxide
European Commission
EU Cosmetic Ingredient Database (CosIng)
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Potassium Hydroxide
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Stearamine Oxide
European Commission
EU Cosmetic Ingredient Database (CosIng)
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Superoxide Dismutase
European Commission
EU Cosmetic Ingredient Database (CosIng)
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Tin Oxide
European Commission
EU Cosmetic Ingredient Database (CosIng)
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Titanium Dioxide
European Commission
EU Cosmetic Ingredient Database (CosIng)
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Titanium Dioxide (Ci 77891)
European Commission
EU Cosmetic Ingredient Database (CosIng)
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Trimethylbenzoyl Diphenylphosphine Oxide
European Commission
EU Cosmetic Ingredient Database (CosIng)
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Zinc Ascorbate Hydroxide
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Zinc Carbonate Hydroxide
European Commission
EU Cosmetic Ingredient Database (CosIng)
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Zinc Oxide
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized stud
Dal Belo SE, Kanoun-Copy L, Lambert C, Cornillon C, Muller B et al.
Journal of cosmetic dermatology, 2024
→
Probiotic, Paraprobiotic, and Hydrolyzed Yeast Mixture Supplementation Has Comparable Effects to Zinc Oxide in Improving Growth Performance and Amelio
Dang X, Choi SY, Choi YJ, Lee JH, Castex M et al.
Probiotics and antimicrobial proteins, 2024
→
Microstructural, Fluid Dynamic, and Mechanical Characterization of Zinc Oxide and Magnesium Chloride-Modified Hydrogel Scaffolds.
de Mello Innocentini MD, Fuzatto Bueno BR, Urbaś A, Morawska-Chochół A
ACS biomaterials science & engineering, 2024
→
Developing a stable aqueous enteric coating formulation with hydroxypropyl methylcellulose acetate succinate (HPMCAS-MF) and colloidal silicon dioxide
Deshpande TM, Quadir A, Obara S, Ibrahim A, Hoag SW
International journal of pharmaceutics, 2018
→
Safety of titanium dioxide nanoparticles in cosmetics.
B Dréno, A Alexis, B Chuberre, M Marinovich
Journal of the European Academy of Dermatology and Venereology : JEADV, 2019
→
Safety of titanium dioxide nanoparticles in cosmetics.
B Dréno, A Alexis, B Chuberre, M Marinovich
Journal of the European Academy of Dermatology and Venereology : JEADV, 2019
→
Safety of titanium dioxide nanoparticles in cosmetics.
B Dréno, A Alexis, B Chuberre, M Marinovich
Journal of the European Academy of Dermatology and Venereology : JEADV, 2019
→
Safety of titanium dioxide nanoparticles in cosmetics.
B Dréno, A Alexis, B Chuberre, M Marinovich
Journal of the European Academy of Dermatology and Venereology : JEADV, 2019
→
Safety and efficacy of a super critical carbon dioxide extract of Humulus lupulus L. flos when used as a feed flavouring for all animal species.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, Bastos ML, Christensen H et al.
EFSA journal. European Food Safety Authority, 2018
→
Aluminum Hydroxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Ammonium Hydroxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Boron Oxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
C30-45 Alkyl Dimethicone/Polycyclohexene Oxide Crosspolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Calcium Hydroxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Cocamidopropylamine Oxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hydrogen Peroxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Iron Dioxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Iron Hydroxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Lauramine Oxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Magnesium Hydroxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Magnesium Oxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Potassium Hydroxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Sodium Hydroxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Stearamine Oxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
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Superoxide Dismutase
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Tin Oxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
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Titanium Dioxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Trimethylbenzoyl Diphenylphosphine Oxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Zinc Carbonate Hydroxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Zinc Oxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Protective effect of oat bran extracts on human dermal fibroblast injury induced by hydrogen peroxide.
Feng B, Ma LJ, Yao JJ, Fang Y, Mei YA et al.
Journal of Zhejiang University. Science. B, 2013
→
Protective effect of oat bran extracts on human dermal fibroblast injury induced by hydrogen peroxide.
Feng B, Ma LJ, Yao JJ, Fang Y, Mei YA et al.
Journal of Zhejiang University. Science. B, 2013
→
Limonene Hydroperoxides.
Anton de Groot
Dermatitis : contact, atopic, occupational, drug, 2019
→
Use of Agave tequilana-lignin and zinc oxide nanoparticles for skin photoprotection.
Gutiérrez-Hernández JM, Escalante A, Murillo-Vázquez RN, Delgado E, González FJ et al.
Journal of photochemistry and photobiology. B, Biology, 2016
→
b) As stabilizers for hydrogen peroxide in leave-on hair products
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
b) In combination with hydrogen peroxide
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
b) Oral products containing peroxides or peroxide-generating compounds Manufacturers should have the following information on hand as it may be requested by Health Canada: A labor
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Benzoyl peroxide
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Calcium peroxide
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Dimethyl sulfoxide
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Ethylene oxide
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Hydrogen peroxide
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Magnesium peroxide
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Peroxide and peroxide-generating compounds
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Urea (carbamide) peroxide
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Zinc peroxide
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Polymerization of Ethylene Oxide, Propylene Oxide, and Other Alkylene Oxides: Synthesis, Novel Polymer Architectures, and Bioconjugation.
Herzberger J, Niederer K, Pohlit H, Seiwert J, Worm M et al.
Chemical reviews, 2016
→
Biocompatible zinc oxide nanocrystals stabilized via hydroxyethyl cellulose for mitigation of diabetic complications.
Hussein J, El-Banna M, Razik TA, El-Naggar ME
International journal of biological macromolecules, 2018
→
Biofabrication of zinc oxide nanoparticles using fruit extract of Rosa canina and their toxic potential against bacteria: A mechanistic approach.
Jafarirad S, Mehrabi M, Divband B, Kosari-Nasab M
Materials science & engineering. C, Materials for biological applications, 2016
→
Efficacy of zinc glycinate reducing zinc oxide on intestinal health and growth of nursery pigs challenged with F18+ Escherichia coli.
Jang KB, Moita VHC, Martinez N, Sokale A, Kim SW
Journal of animal science, 2023
→
"Green"-synthesized zinc oxide nanoparticles and plant extracts: A comparison between synthesis processes and antihyperglycemic activity.
Kambale EK, Katemo FM, Quetin-Leclercq J, Memvanga PB, Beloqui A
International journal of pharmaceutics, 2023
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Direct synthesis of dimethyl carbonate from methanol and carbon dioxide over CeO2(X)-ZnO(1-X) nano-catalysts.
Kang KH, Joe W, Lee CH, Kim M, Kim DB et al.
Journal of nanoscience and nanotechnology, 2013
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Dimethyl sulfoxide (DMSO): a solvent that may solve selected cutaneous clinical challenges.
Karim M, Boikess RS, Schwartz RA, Cohen PJ
Archives of dermatological research, 2023
→
Dimethyl sulfoxide (DMSO): a solvent that may solve selected cutaneous clinical challenges.
Karim M, Boikess RS, Schwartz RA, Cohen PJ
Archives of dermatological research, 2023
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Role of architecture of N-oxide surfactants in the design of nanoemulsions for Candida skin infection.
Lewińska A, Jaromin A, Jezierska J
Colloids and surfaces. B, Biointerfaces, 2020
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Induction of a non-rhythmic motor pattern by nitric oxide in hatchling Rana temporaria embryos.
McLean DL, McDearmid JR, Sillar KT
The Journal of experimental biology, 2001
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Antimicrobial effect of hydro-alcoholic extract of apple with and without zinc oxide nanoparticles on Streptococcus Mutans.
Mehrabkhani M, Movahhed T, Arefnezhad M, Hamedi S, Faramarzian F
European journal of translational myology, 2023
→
The Influence of Zinc Oxide and Zinc Stearate on the Antimicrobial Activity of Coatings Containing Raspberry and Chokeberry Extracts.
Mizielińska M, Bartkowiak A
Molecules (Basel, Switzerland), 2024
→
Properties and applications of calcium hydroxide in endodontics and dental traumatology.
Mohammadi Z, Dummer PM
International endodontic journal, 2011
→
Extracellular synthesis of zinc oxide nanoparticle using seaweeds of gulf of Mannar, India.
Nagarajan S, Arumugam Kuppusamy K
Journal of nanobiotechnology, 2013
→
Limonene and linalool hydroperoxides review: Pros and con...
Isabel A Ogueta, Johanna Brared Christensson, Elena Giménez-Arnau, Richard Brans, Mark Wilkinson, Luca Stingeni + 5 more
Contact dermatitis, 2022
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Limonene and linalool hydroperoxides review: Pros and con...
Isabel A Ogueta, Johanna Brared Christensson, Elena Giménez-Arnau, Richard Brans, Mark Wilkinson, Luca Stingeni + 5 more
Contact dermatitis, 2022
→
Limonene and linalool hydroperoxides review: Pros and con...
Isabel A Ogueta, Johanna Brared Christensson, Elena Giménez-Arnau, Richard Brans, Mark Wilkinson, Luca Stingeni + 5 more
Contact dermatitis, 2022
→
Impact of Dietary Zinc Chloride Hydroxide and Zinc Methionine on the Faecal Microbiota of Healthy Adult Horses and Ponies.
Paßlack N, van Bömmel-Wegmann S, Vahjen W, Zentek J
Journal of equine veterinary science, 2022
→
Safety Assessment of Hydroxy Tetramethylpiperidine Oxide and Tris(Tetramethylhydroxypiperidinol) Citrate as Used in Cosmetics.
Raj PS, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
→
Safety Assessment of Hydroxy Tetramethylpiperidine Oxide and Tris(Tetramethylhydroxypiperidinol) Citrate as Used in Cosmetics.
Raj PS, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
→
Efficacy and safety of microencapsulated benzoyl peroxide...
James Del Rosso, Jeffrey Sugarman, Lawrence Green, Theodore Lain, Ofra Levy-Hacham, Rinat Mizrahi + 1 more
Journal of the American Academy of Dermatology, 2023
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Combating Lead/HFD Neurotoxicity in Rats: The Synergistic Effect of 10-Hydroxydecanoic Acid and Zinc Oxide Nanoparticles.
Saleh SR, Atef E, Maher AM, Ghareeb DA, Sheta E et al.
Biological trace element research, 2026
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In vitro skin decontamination of the organophosphorus pesticide Paraoxon with nanometric cerium oxide CeO(2).
Salerno A, Devers T, Bolzinger MA, Pelletier J, Josse D et al.
Chemico-biological interactions, 2017
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A review of inorganic UV filters zinc oxide and titanium ...
Samantha L Schneider, Henry W Lim
Photodermatology, photoimmunology & photomedicine, 2019
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Phenolic-enriched maple syrup extract protects human keratinocytes against hydrogen peroxide and methylglyoxal induced cytotoxicity.
Sheng J, Liu C, Petrovas S, Wan Y, Chen HD et al.
Dermatologic therapy, 2020
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Co-pyrolysis of sunflower-oil cake with potassium carbonate and zinc oxide using plasma torch to produce bio-fuels.
Shie JL, Chang CC, Chang CY, Tzeng CC, Wu CY et al.
Bioresource technology, 2011
→
Zinc Oxide Nanoparticle as a Novel Class of Antifungal Ag...
Qi Sun, Jianmei Li, Tao Le
Journal of agricultural and food chemistry, 2018
→
Comparative study of titanium dioxide to improve the quality of finished cosmetic products.
Świątczak D, Belica-Pacha S, Zawisza A, Kisielewska A, Światły-Błaszkiewicz A et al.
International journal of cosmetic science, 2023
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Preparation of porous antibacterial polyamide 6 (PA6) membrane with zinc oxide (ZnO) nanoparticles selectively localized at the pore walls via reactiv
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The Science of the total environment, 2020
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BSA Adsorption on Titanium Dioxide Nanoparticle Surfaces ...
Raweewan Thiramanas, Yodsathorn Wongngam, Goragot Supanakorn, Duangporn Polpanich
ACS applied bio materials, 2024
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Phenazine derivatives as the mutagenic reaction product from o- or m-phenylenediamine derivatives with hydrogen peroxide.
Watanabe T, Hirayama T, Fukui S
Mutation research, 1989
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Hollow manganese dioxide-chitosan hydrogel for the treatm...
Yaguang Wu, Zihao Zhou, Min Zhang, Song Li, Mengyi Sun, Zhiqiang Song
Journal of nanobiotechnology, 2023
→
Development of magnesium hydroxide-doped nanofibrous spheres for repairing infected skin wounds.
You Y, Ning X, Zhang X, Wang Y, Zhang Y et al.
Biomaterials advances, 2024
→
Purification of Spent Hop Cone (Humulus lupulus L.) Extract with Xanthohumol Using Mesoporous Superparamagnetic Iron Oxide Nanoparticles.
Żuk N, Pasieczna-Patkowska S, Grabias-Blicharz E, Pizoń M, Flieger J
Antioxidants (Basel, Switzerland), 2025
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Verified Jun 2026
Data: PubChem · CosIng