Oxyquinoline
AKA “8-HYDROXYQUINOLINE, quinolin-8-ol, 8-quinolinol, Oxine, Quinophenol, Oxychinolin, Phenopyridine, 8-Quinol
Synthetic
Ingredient Facts
Oxyquinoline
AKA: 8-HYDROXYQUINOLINE, Quinolin-8-ol, 8-quinolinol, Oxine, Quinophenol, Oxychinolin, Phenopyridine, 8-Quinol
Synthetic · Antimicrobial · EWG: 5
Synthetic
Preservative
Chelating Agent
Synthetic
Clean
A naturally-derived preservative that protects products from microbial growth and helps stabilize formulations for longer shelf life.
Solubility less than 1 mg/mL at 61 °F (NTP, 1992)
Formula
C9H7NO
Mol. Weight
145.16
CAS #
148-24-3
Form
Powder
State
8-hydroxyquinoline appears as white to off-white or faintly yellow crystalline powder. Phenolic odor. (NTP, 1992)
See origin →
Functions
Antimicrobial
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Chelating
Grabs onto metal ions in water that would destabilize the formula. Keeps your product from going bad or changing color.
Fights Bacteria
Traditional Use
Developed in the early 20th century as an antimicrobial and antifungal synthetic agent. It has been used in cosmetics and topical preparations to preserve products and treat minor skin irritations.
Skin Types
all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
No
EWG
5
CIR
Unsafe
Pregnancy
No
CIR Safety Findings
medical-approval
all-shades-safe
Concentration Guide
0.3%
0%0%
Reg. Limit
EU regulatory limit: 0.3%. (a) 0.3% (as base) (b) 0.03% (as base) Source: EU Cosmetics Regulation (EC) 1223/2009, Annex III (Restricted Substances), Entry 51.
Regulatory Status
USArestricted
EUpermitted
JAPANpermitted
CANADArestricted
Final amended report on the safety assessment of oxyquinoline and oxyquinoline sulfate as used in cosmetics.
Andersen A
International journal of toxicology, 2006
Final amended report on the safety assessment of oxyquinoline and oxyquinoline sulfate as used in cosmetics.
Andersen A
International journal of toxicology, 2006
Final Amended Report on the Safety of Oxyquinoline and Oxyquinoline Sulfate as used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Oxyquinoline and Oxyquinoline Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Oxyquinoline
European Commission
EU Cosmetic Ingredient Database (CosIng)
Oxyquinoline Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
Oxyquinoline
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Oxyquinoline Sulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
8-Hydroxyquinoline and its sulfate
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Thyroxine and treatment of hypothyroidism: seven decades of experience.
Mateo RCI, Hennessey JV
Endocrine, 2019
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR