Oxyquinoline Sulfate
AKA “8-Hydroxyquinoline sulfate, Hydroxyquinoline sulfate, Oxine sulfate, oxyquinoline sulphate, 8-Quinolinol sulfate (2:1) (salt), DTXSID6025436, 61VUG75Y3P, DTXCID605436, CRIPTONOL
Ingredient
Ingredient Facts
Oxyquinoline sulfate
AKA: 8-Hydroxyquinoline sulfate, Hydroxyquinoline sulfate, Oxine sulfate, Oxyquinoline sulphate, 8-Quinolinol sulfate (2:1) (salt), DTXSID6025436, 61VUG75Y3P, DTXCID605436, CRIPTONOL
Ingredient · Antimicrobial · EWG: 6
Synthetic
Preservative
Chelating Agent
Not Clean
bis(8-Hydroxyquinolinium) sulphate
Solubility greater than or equal to 100 mg/mL at 66 °F (NTP, 1992)
Formula
C18H16N2O6S
Mol. Weight
388.40
CAS #
134-31-6
Form
Powder
State
8-hydroxyquinoline sulfate is a pale yellow to yellow crystalline powder with a slight saffron odor. Burning taste. (NTP, 1992)
See origin →
Functions
Antimicrobial
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Chelating
Grabs onto metal ions in water that would destabilize the formula. Keeps your product from going bad or changing color.
Fights Bacteria
Traditional Use
The sulfate salt form of oxyquinoline was developed as a more stable antimicrobial preservative for cosmetics. It has been used since the early-to-mid 20th century as a preservative and anti-fungal agent.
Skin Types
all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
No
EWG
6
CIR
Insufficient data
Pregnancy
No
CIR Safety Findings
all-shades-safe
Concentration Guide
0.3%
0%0%
Reg. Limit
EU regulatory limit: 0.3%. (a) 0.3% (as base) (b) 0.03% (as base) Source: EU Cosmetics Regulation (EC) 1223/2009, Annex III (Restricted Substances), Entry 51.
Regulatory Status
USAunder review
EUpermitted
JAPANpermitted
CANADApermitted
Final amended report on the safety assessment of oxyquinoline and oxyquinoline sulfate as used in cosmetics.
Andersen A
International journal of toxicology, 2006
Final amended report on the safety assessment of oxyquinoline and oxyquinoline sulfate as used in cosmetics.
Andersen A
International journal of toxicology, 2006
Final Amended Report on the Safety of Oxyquinoline and Oxyquinoline Sulfate as used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Oxyquinoline and Oxyquinoline Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Oxyquinoline Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
Oxyquinoline Sulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR