Palmitoyl Proline
AKA “59441-32-6, 1-(1-Oxohexadecyl)-L-proline, L-Proline, 1-(1-oxohexadecyl)-, I49727TDYF, SEPIFEEL ONE, EINECS 261-763-5, N-PALMITOYL-L-PROLINE, RefChem:858433, PALMITOYL PROLINE [INCI]
Skin Conditioning
Ingredient Facts
Palmitoyl proline
AKA: 59441-32-6, 1-(1-Oxohexadecyl)-L-proline, L-Proline, 1-(1-oxohexadecyl)-, I49727TDYF, SEPIFEEL ONE, EINECS 261-763-5, N-PALMITOYL-L-PROLINE, RefChem:858433, PALMITOYL PROLINE [INCI]
Skin Conditioning · Hair Conditioning · EWG: 1
Synthetic
Skin Conditioner
Hair Care
Amino Acid
Clean
The panel concluded that the 115 amino acid alkyl amides listed below are safe in the present practices of use and concentration in cosmetics, when formulated to be non-irritating...Palmitoyl Proline...
Formula
C21H39NO3
Mol. Weight
353.50
CAS #
59441-32-6
Form
Powder
See origin →
Functions
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
A synthetic amino acid conjugate made by attaching palmitic acid to proline. Designed as a modern skincare ingredient to improve hydration and support skin firmness.
Skin Types
all-skin-types
Best For
Loss of Elasticity
Pregnancy & Breastfeeding Safe
Yes
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USApermitted
CANADApermitted
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR