Panthenyl Ethyl Ether Acetate
AKA “UNII-S2FA5ZM21C, S2FA5ZM21C, Panthenyl ethyl ether acetate [INCI], 119516-54-0, Butanamide, 4-(acetyloxy)-N-(3-ethoxypropyl)-2-hydroxy-3, 3-dimethyl-, (2R)-, (R)-, DTXSID50152482, RefChem:169901, DTXCID5074973
Hair Conditioning
Ingredient Facts
Panthenyl ethyl ether acetate
AKA: UNII-S2FA5ZM21C, S2FA5ZM21C, Panthenyl ethyl ether acetate [INCI], 119516-54-0, Butanamide, 4-(acetyloxy)-N-(3-ethoxypropyl)-2-hydroxy-3, 3-dimethyl-, (2R)-, (R)-, DTXSID50152482, RefChem:169901, DTXCID5074973
Hair Conditioning · Antistatic · EWG: 4
Synthetic
Skin Conditioner
Hair Care
B Vitamin
Not Clean
Butanamide, 2-hydroxy-4-acetyloxy-3,3-dimethyl-N-(3-ethoxypropyl)-
Formula
C13H25NO5
Mol. Weight
275.34
CAS #
667-83-4
Form
Liquid
See origin →
Functions
Antistatic
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Reduces Static
Conditions Hair
Antioxidant Protection
Reduces Inflammation
Wound Healing
Reduces flyaways
Softens and detangles hair
Traditional Use
Developed in the mid-20th century as a synthetic derivative of panthenol (vitamin B5). Created to provide improved stability and skin penetration compared to panthenol, while maintaining moisturizing and conditioning benefits in cosmetics.
Skin Types
all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
medical-approval
all-shades-safe
Mild Irritant
Regulatory Status
USApermitted
CANADApermitted
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR