Pentylene Glycol
AKA “1, 2-Pentanediol, 5343-92-0, 2-Dihydroxypentane, NSC-513, 50C1307PZG, DTXSID10863522, RefChem:860099, DTXCID80812123, 226-285-3”
Skin Conditioning
Ingredient Facts
Pentylene glycol
AKA: 1, 2-Pentanediol, 5343-92-0, 2-Dihydroxypentane, NSC-513, 50C1307PZG, DTXSID10863522, RefChem:860099, DTXCID80812123, 226-285-3
Skin Conditioning · Skin Conditioning · EWG: 2
Synthetic
Solvent
Skin Conditioner
Clean
structure in first source
Effective at 2.5%
Formula
C5H12O2
Mol. Weight
104.15
CAS #
5343-92-0
Form
Liquid
State
Liquid
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Solvent
Dissolves other ingredients so they distribute evenly in the formula. Often the invisible "base" everything else is mixed into.
Locks in moisture
Traditional Use
A synthetic humectant and preservative booster developed in the late 20th century. Created to improve hydration and product stability in modern skincare formulations.
Skin Types
●all-skin-types, gentle
Best For
Dehydration
Pregnancy & Breastfeeding Safe
Yes
EWG
2
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
ewg-2
medical-approval
pregnancy-nursing-safe
all-shades-safe
Potential Sensitizer
Concentration Guide
0.005%
5.0%
0%7%
Effective Range
CIR reported use: 0.3-5 | 0.005-4
Regulatory Agencies
Slip Tint™ Undetectable Baked Setting Powder
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CitySet™ Lightweight Setting Spray 95ml
Saie
Mini CitySet™ Lightweight Setting Spray
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advanced retinol gel 0.5%
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peptide fine line eye gel
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travel-size Electrolyte Water Cream
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hydration heroes set
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calm & clarify duo
Cocokind
beginner retinol gel 0.1%
Cocokind
rise + shine trio
Cocokind
retinol face + body duo
Cocokind
youthful duo
Cocokind
Rewakening™ Rosewater Mist
COOLA
Hydrating Sunscreen Lotion - Peach Blossom
COOLA
3 Piece Classic Suncare Travel Set
COOLA
Suncare Travel Essentials Set
COOLA
the body duo
Agent Nateur
the lash growth duo
Agent Nateur
the anti aging day and night ritual
Agent Nateur
lactic acid cleanser duo
Agent Nateur
the vitamin c and hyaluronic brightening duo
Agent Nateur
holi (lift) ageless lifting and firming serum deluxe mini
Agent Nateur
the after (glow) set: ruby
Agent Nateur
the after (glow) set: rose quartz
Agent Nateur
Hyaluronic Acid 0.3% Hydrating Booster
Pai Skincare
Bonne Nuit™ Night Cream
Pai Skincare
Fade Forward™ Serum
Pai Skincare
Phytofill™ 1% Firming Booster
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Vegan Collagen 0.9% Restoring Booster
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Salicylic Acid 2% Clarifying Booster
Pai Skincare
C-2 Believe™ Moisturizer
Pai Skincare
Tri-Mushroom 10% Super-Soothing Booster
Pai Skincare
Gentle Genius™ Barrier Care Wet Skin Moisturizer
Pai Skincare
Purifying Face Wash
Indie Lee
Brightening Cream
Indie Lee
Gentle Daily Peel
Indie Lee
AHA Exfoliating Solution
Indie Lee
Double Cleanse for Balanced & Combo Skin
Indie Lee
Double Cleanse for Dry or Mature Skin
Indie Lee
Clean & Comfort Duo
Indie Lee
Meltaway Gel-Milk Cleanser (100mL)
Grown Alchemist
Skin Defense Primer (50mL)
Grown Alchemist
Revitalize Hand Wash (500mL)
Grown Alchemist
Energize Body Cleanser (50mL)
Grown Alchemist
Tulip Tint Lip & Cheek Balm
Bloom Effects
Tulip Dew Sunscreen Serum
Bloom Effects
Black Tulip Eye Treatment
Bloom Effects
Radiance Reset
Bloom Effects
Everyday Radiance Essentials
Bloom Effects
Making Moves Milky Cleanser
Ursa Major
Pentylene Glycol
European Commission
EU Cosmetic Ingredient Database (CosIng)
Pentylene Glycol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Margin of safety of pentylene glycol derived using measurements of cutaneous absorption and volatility.
Steiner A, Kugarajan K, Wullimann M, Ruty B, Kunze G
Regulatory toxicology and pharmacology : RTP, 2017
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR