Phosphatidylserine
AKA “Phosphotidylserine, Distearoylphosphatidylserine, 394XK0IH40, 1446756-47-3, (2S)-2-amino-3-[[(2R)-2, 3-di(octadecanoyloxy)propoxy]-hydroxyphosphoryl]oxypropanoic acid, Phosphatidyl Serines, Serine, Phosphatidyl, Serines, Serine Phosphoglycerides”
Skin Conditioning
Ingredient Facts
Phosphatidylserine
AKA: Phosphotidylserine, Distearoylphosphatidylserine, 394XK0IH40, 1446756-47-3, (2S)-2-amino-3-[[(2R)-2, 3-di(octadecanoyloxy)propoxy]-hydroxyphosphoryl]oxypropanoic acid, Phosphatidyl Serines, Serines, Serine Phosphoglycerides
Skin Conditioning · Emulsion Stabilising · EWG: 1
Synthetic
Emulsifier
Skin Conditioner
Barrier Support
Hair Care
Plant Oil
Clean
Fatty acid diglycerides, phosphate monoesters, 2-amino-2-carboxyethyl ester
Formula
C42H82NO10P
Mol. Weight
792.10
CAS #
1446756-47-3
Form
Powder
State
Solid
See origin →
Functions
Emulsion Stabilising
Forces oil and water to stay mixed instead of separating into layers. The unsung hero holding your lotion together.
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Protecting
Helps rebuild and strengthen your skin barrier — the invisible shield that keeps moisture in and irritants out. Essential after over-exfoliating or harsh weather.
Nourishes & Protects
Traditional Use
A naturally occurring phospholipid found in cell membranes; discovered in the 20th century. Used in modern cosmetics as a skin-conditioning ingredient and potential anti-aging agent.
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
Industry Max
Industry typically uses up to 2.0% in leave-on products (9 products reported). Source: CIR Safety Assessment (CIR Seq 607).
Regulatory Agencies
Influence of Oil Polarity and Cosurfactants on the Foamability of Mono- and Diacylphosphatidylcholine Stabilized Emulsions.
Bunk M, Daniels R
Pharmaceutics, 2022
Effects of ethanol and diclofenac on the organization of hydrogenated phosphatidylcholine bilayer vesicles and their ability as skin carriers.
Castangia I, Manca ML, Matricardi P, Catalán-Latorre A, Nácher A et al.
Journal of materials science. Materials in medicine, 2015
Dipeptidyl peptidase-1 inhibition with brensocatib reduces the activity of all major neutrophil serine proteases in patients with bronchiectasis: resu
Cipolla D, Zhang J, Korkmaz B, Chalmers JD, Basso J et al.
Respiratory research, 2023
Ammonium Phosphatidyl Rapeseedate
European Commission
EU Cosmetic Ingredient Database (CosIng)
Hydrogenated Lysophosphatidylcholine
European Commission
EU Cosmetic Ingredient Database (CosIng)
Hydrogenated Phosphatidylcholine
European Commission
EU Cosmetic Ingredient Database (CosIng)
Lysophosphatidylethanolamine
European Commission
EU Cosmetic Ingredient Database (CosIng)
Lysophosphatidylglycerol
European Commission
EU Cosmetic Ingredient Database (CosIng)
Phosphatidylcholine
European Commission
EU Cosmetic Ingredient Database (CosIng)
Phosphatidylglycerol
European Commission
EU Cosmetic Ingredient Database (CosIng)
Phosphatidylinositol
European Commission
EU Cosmetic Ingredient Database (CosIng)
Phosphatidylserine
European Commission
EU Cosmetic Ingredient Database (CosIng)
Serine
European Commission
EU Cosmetic Ingredient Database (CosIng)
Hydrogenated Lysophosphatidylcholine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Hydrogenated Phosphatidylcholine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Phosphatidylcholine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Phosphatidylglycerol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Phosphatidylserine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Serine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Eserine and its salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Lipidome changes indicate oxidative stress, inflammation, and specific loss of glycerophosphoserine inflammatory protection in patients with lupus.
Koelmel JP, Ramos PS, Costa KA, Godri-Pollitt KJ, Kamen DL et al.
Journal of pharmaceutical and biomedical analysis, 2026
Mesotherapy and phosphatidylcholine injections: historica...
Adam M Rotunda, Michael S Kolodney
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2006
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR