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Polyglyceryl-4 Isostearate
AKA “Isostearic Acid Polyglyceryl Ester, Emollient”
Surfactant
Ingredient Facts
Polyglyceryl-4 isostearate
AKA: Isostearic Acid Polyglyceryl Ester, Emollient
Surfactant · Emulsifying · EWG: 1
Plant-Derived
Cleanser
Emulsifier
Clean
1,2,3-Propanetriol, homopolymer, isooctadecanoates (1:1) (4 mol glycerol average molar ratio)
CAS #
-
See origin →
Functions
Emulsifying
Forces oil and water to stay mixed instead of separating into layers. The unsung hero holding your lotion together.
Emulsifier
Antioxidant Protection
Reduces Inflammation
Locks In Moisture
Mixes Oil & Water
Traditional Use
Developed as a branched-chain polyglyceryl emulsifier for improved spreadability and skin feel. Designed as an alternative to straight-chain emulsifiers for premium cosmetic formulations.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Adverse Events from Emollient Use in Eczema: A Restricted Review of Published Data.
Bhanot A, Huntley A, Ridd MJ
Dermatology and therapy, 2019
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Measurement of the biomechanical function and structure of ex vivo drying skin using raman spectral analysis and its modulation with emollient mixture
Biniek K, Tfayli A, Vyumvuhore R, Quatela A, Galliano MF et al.
Experimental dermatology, 2018
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Measurement of the biomechanical function and structure of ex vivo drying skin using raman spectral analysis and its modulation with emollient mixture
Biniek K, Tfayli A, Vyumvuhore R, Quatela A, Galliano MF et al.
Experimental dermatology, 2018
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Polyglyceryl-4 Isostearate
European Commission
EU Cosmetic Ingredient Database (CosIng)
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Polyglyceryl-4 Isostearate/Laurate
European Commission
EU Cosmetic Ingredient Database (CosIng)
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Emollients are more than sensory ingredients: the case of isostearyl isostearate.
Dederen JC, Chavan B, Rawlings AV
International journal of cosmetic science, 2012
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Polyglyceryl-4 Isostearate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
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Restoring Skin Hydration and Barrier Function: Mechanistic Insights Into Basic Emollients for Xerosis Cutis.
Fluhr JW, Muguet V, Christen-Zaech S
International journal of dermatology, 2025
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Efficacy of an emollient containing diethylene glycol/dilinoleic acid copolymer for the treatment of dry skin and pruritus in patients with senile xer
Izumi R, Negi O, Suzuki T, Tominaga M, Kamo A et al.
Journal of cosmetic dermatology, 2017
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Contact dermatitis caused by polyacrylamide/C13-4 isoparaffin/laureth-7 mix in an emollient cream for atopic skin.
Jaulent C, Dereure O, Raison-Peyron N
Contact dermatitis, 2019
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Effect of emollients on UV filter absorbance and sunscreen efficiency.
Sohn M, Amorós-Galicia L, Krus S, Martin K, Herzog B
Journal of photochemistry and photobiology. B, Biology, 2020
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Effect of emollients on UV filter absorbance and sunscreen efficiency.
Sohn M, Amorós-Galicia L, Krus S, Martin K, Herzog B
Journal of photochemistry and photobiology. B, Biology, 2020
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Effect of emollients on UV filter absorbance and sunscreen efficiency.
Sohn M, Amorós-Galicia L, Krus S, Martin K, Herzog B
Journal of photochemistry and photobiology. B, Biology, 2020
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Efficacy of a Rhealba® Oat Extract-based emollient on chr...
J Theunis, H Chaussade, O Bourgeois, V Mengeaud
Journal of the European Academy of Dermatology and Venereology : JEADV, 2017
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Efficacy of a Rhealba® Oat Extract-based emollient on chr...
J Theunis, H Chaussade, O Bourgeois, V Mengeaud
Journal of the European Academy of Dermatology and Venereology : JEADV, 2017
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Efficient Development of Green Emulsifier/Emollient-Based Emulsion Vehicles: From RSM Optimal Experimental Design to Abridged In Vivo Assessment.
Vukašinović M, Savić S, Cekić N, Ilić T, Pantelić I et al.
Pharmaceutics, 2023
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Efficient Development of Green Emulsifier/Emollient-Based Emulsion Vehicles: From RSM Optimal Experimental Design to Abridged In Vivo Assessment.
Vukašinović M, Savić S, Cekić N, Ilić T, Pantelić I et al.
Pharmaceutics, 2023
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Efficient Development of Green Emulsifier/Emollient-Based Emulsion Vehicles: From RSM Optimal Experimental Design to Abridged In Vivo Assessment.
Vukašinović M, Savić S, Cekić N, Ilić T, Pantelić I et al.
Pharmaceutics, 2023
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Efficient Development of Green Emulsifier/Emollient-Based Emulsion Vehicles: From RSM Optimal Experimental Design to Abridged In Vivo Assessment.
Vukašinović M, Savić S, Cekić N, Ilić T, Pantelić I et al.
Pharmaceutics, 2023
→
Efficient Development of Green Emulsifier/Emollient-Based Emulsion Vehicles: From RSM Optimal Experimental Design to Abridged In Vivo Assessment.
Vukašinović M, Savić S, Cekić N, Ilić T, Pantelić I et al.
Pharmaceutics, 2023
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Verified Jun 2026
Data: CosIng · EWG · CIR