Polyurethane-64
AKA “Polyurethane
Ingredient
Ingredient Facts
Polyurethane-64
Ingredient · Film Forming · EWG: 4
Synthetic
Occlusive
Not Clean
Polyurethane-64 is a urethane copolymer formed by a multi-step reaction. First, isophorone diisocyanate (IDPI) is reacted with a mixture of polytetrahydrofurans (PTHFs), also known as polybutylene glycols or polytetramethylene glycols. One of the PTHFs contains an average of 14 mols and the other an average of 28 mols of butylene glycol. The resulting polyurethane is reacted with 4,4'-methylenebis(cyclohexylamine) and finally the residual isocyanate groups are reacted with ethanol.
Form
Powder
See origin →
Functions
Film Forming
Creates a physical seal on skin to lock moisture in and keep irritants out. The "slugging" ingredient — barrier protection.
Creates Protective Barrier
Traditional Use
A synthetic polymer developed in the mid-20th century for industrial applications. Used in cosmetics as a film-forming agent and texture modifier in formulations like foundations and primers.
Skin Types
all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Polyurethane Versus Calcium Alginate Dressings for Split-Thickness Skin Graft Donor Site: A Systematic Review and Meta-Analysis.
Alsaif A, Karam M, Aldubaikhi AA, Alghufaily A, Alhuwaishel K et al.
Cureus, 2021
Bactericidal ZnO glass-filled thermoplastic polyurethane and polydimethyl siloxane composites to inhibit biofilm-associated infections.
Cabal B, Sevillano D, Fernández-García E, Alou L, Suárez M et al.
Scientific reports, 2019
Final Report: Safety Assessment of Polyurethanes as Used as Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Polyurethane-11
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-12
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-13
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-15
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-16
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-17
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-2
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-20
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-21
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-23
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-25
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-26
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-27
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-28
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-32
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-33
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-34
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-35
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-36
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-39
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-4
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-40
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-41
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-42
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-43
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-44
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-45
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-47
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-48
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-49
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-5
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-50
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-51
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-52
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-53
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-54
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-55
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-56
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-57
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-58
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-59
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-60
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-61
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-62
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-63
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-64
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-65
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-66
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-67
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-68
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-7
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-8
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-9
European Commission
EU Cosmetic Ingredient Database (CosIng)
Polyurethane-11
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Polyurethane-15
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Polyurethane-2
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Polyurethane-35
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Verified Jun 2026
Data: CosIng · EWG · CIR