Propyl Gallate
AKA “121-79-9, Propyl 3, 4, 5-trihydroxybenzoate, N-Propyl gallate, Progallin P, Gallic acid, propyl ester, Tenox PG, Nipagallin P, Gallic acid propyl ester, NIPA 49
Antioxidant
Ingredient Facts
Propyl gallate
AKA: 121-79-9, Propyl 3, 4, 5-trihydroxybenzoate, N-Propyl gallate, Progallin P, Gallic acid, Propyl ester, Tenox PG, Nipagallin P, Gallic acid propyl ester, NIPA 49
Antioxidant · Antioxidant · EWG: 4
Synthetic
Antioxidant
Fragrance
Phenolic Acid
Not Clean
Propyl 3,4,5-trihydroxybenzoate
Solubility less than 1 mg/mL at 68 °F (NTP, 1992)
Formula
C10H12O5
Mol. Weight
212.20
CAS #
121-79-9
Form
Liquid
State
Propyl gallate appears as fine white to creamy-white crystalline powder. Odorless or with a faint odor. Melting point 150 °C. Insoluble in water. Slightly bitter taste.
See origin →
Functions
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Perfuming
Added for scent. Can be natural or synthetic. Common irritant and allergen — one of the top reasons people react to products.
Neutralizes Free Radicals
Traditional Use
Developed in the early 20th century as a synthetic antioxidant derived from gallic acid (found in plant tannins). Used since the 1940s in cosmetics and food preservation to prevent oxidative degradation and rancidity in formulations containing oils.
Skin Types
all-skin-types
Best For
Sun Damage
Pregnancy & Breastfeeding Safe
Caution
EWG
4
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
medical-approval
all-shades-safe
Potential Sensitizer
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Final Report on the Amended Safety Assessment of Propyl Gallate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Propyl Gallate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Isopropyl Ester of PVM/MA Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
Propyl Gallate
European Commission
EU Cosmetic Ingredient Database (CosIng)
Isopropyl Ester of PVM/MA Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Propyl Gallate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Pharmacokinetic and toxicological overview of propyl gallate food additive.
Javaheri-Ghezeldizaj F, Alizadeh AM, Dehghan P, Ezzati Nazhad Dolatabadi J
Food chemistry, 2023
Gallic Acid: A Potent Antioxidant and Anti-inflammatory A...
Urvashi Saini, Anjali Sharma, Vishnu Mittal
Recent advances in drug delivery and formulation, 2026
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR