Propylene Glycol Dicaproate
AKA “Propylene glycol dihexanoate, 50343-36-7, Sefsol 220, 1, 2-Propylene glycol dicaproate, 2-Propanediol dihexanoate, FEMA No. 4470, NSC-409891, UNII-L37F145LOT, L37F145LOT”
Emollient
Ingredient Facts
Propylene glycol dicaproate
AKA: Propylene glycol dihexanoate, 50343-36-7, Sefsol 220, 1, 2-Propylene glycol dicaproate, 2-Propanediol dihexanoate, FEMA No. 4470, NSC-409891, UNII-L37F145LOT, L37F145LOT
Emollient · Emollient · EWG: 4
Synthetic
Emollient
Skin Conditioner
Plant Oil
Not Clean
Hexanoic acid, 1-methyl-1,2-ethanediyl ester
Effective at 1.0%
Solubility Practically insoluble or insoluble in water
Formula
C15H28O4
Mol. Weight
272.38
CAS #
50343-36-7
Form
Liquid
State
Clear colourless liquid; Mild fruity to green aroma
See origin →
Functions
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Locks In Moisture
Traditional Use
Synthesized in the late 20th century as a propylene glycol diester. Adopted in contemporary cosmetics as a light emollient and texture enhancer, intended to replicate the feel and moisturizing properties of natural plant oils.
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe as used
Pregnancy
Yes
Restricted By
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
9.9e-05%
2.0%
0%14%
Effective Range
CIR reported use: 0.000099-2
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR