Ribonolactone
AKA “(3R, 4S, 5R)-3, 4-dihydroxy-5-(hydroxymethyl)oxolan-2-one, D-Ribono-gamma-lactone, 64E63NC231, Ribonic acid, gamma-lactone, D-, NSC-1031, RefChem:883599, CHEBI:37434, 226-256-5, D-Ribono-1, 4-lactone
Humectant
Ingredient Facts
Ribonolactone
AKA: (3R, 4S, 5R)-3, 4-dihydroxy-5-(hydroxymethyl)oxolan-2-one, D-Ribono-gamma-lactone, 64E63NC231, Ribonic acid, Gamma-lactone, D-, NSC-1031, RefChem:883599, CHEBI:37434, 226-256-5, D-Ribono-1, 4-lactone
Humectant · Humectant · EWG: 4
Synthetic
Humectant
Not Clean
D-ribono-1,4-lactone is a five-membered form of ribonolactone having D-configuration. It has a role as a metabolite. It is a butan-4-olide and a ribonolactone. It is functionally related to a D-ribonic acid.
Formula
C5H8O5
Mol. Weight
148.11
CAS #
5336-08-3
Form
Liquid
State
Solid
See origin →
Functions
Humectant
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Locks In Moisture
Traditional Use
A synthetic nucleoside derivative developed in the late 20th century for cosmetic and pharmaceutical applications. Created to provide nucleic acid precursors that support cellular function and skin health.
Skin Types
all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
medical-approval
all-shades-safe
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR