Serine
AKA “L-serine, 56-45-1, (S)-2-Amino-3-hydroxypropanoic acid, (S)-Serine, beta-Hydroxyalanine, L-(-)-Serine, L-ser, (2S)-2-amino-3-hydroxypropanoic acid, Serina
Skin Conditioning
Ingredient Facts
Serine
AKA: L-serine, 56-45-1, (S)-2-Amino-3-hydroxypropanoic acid, (S)-Serine, Beta-Hydroxyalanine, L-(-)-Serine, L-ser, (2S)-2-amino-3-hydroxypropanoic acid, Serina
Skin Conditioning · Antistatic · EWG: 1
Synthetic
Skin Conditioner
Hair Care
Amino Acid
Clean
2-Amino-3-hydroxypropanoic acid
Effective at 1.0%
Solubility 425000
Formula
C3H7NO3
Mol. Weight
105.09
CAS #
302-84-1, 56-45-1
Form
Powder
State
Solid; [Merck Index] White powder; [Sigma-Aldrich MSDS]
See origin →
Functions
Antistatic
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
An amino acid discovered in the late 19th century. Identified as a component of skin proteins and incorporated into skincare products in the latter 20th century based on its natural role in skin hydration and barrier function.
Skin Types
all-skin-types
Best For
Dehydration
Pregnancy & Breastfeeding Safe
Yes
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not Phototoxic
medical-approval
all-shades-safe
Concentration Guide
1e-05%
2.0%
0%100%
Effective Range
CIR reported use: 0.0003-0.008 | 0.00001-2 | 0.00003-2
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Dipeptidyl peptidase-1 inhibition with brensocatib reduces the activity of all major neutrophil serine proteases in patients with bronchiectasis: resu
Cipolla D, Zhang J, Korkmaz B, Chalmers JD, Basso J et al.
Respiratory research, 2023
Phosphatidylserine
European Commission
EU Cosmetic Ingredient Database (CosIng)
Serine
European Commission
EU Cosmetic Ingredient Database (CosIng)
Phosphatidylserine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Serine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Eserine and its salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Lipidome changes indicate oxidative stress, inflammation, and specific loss of glycerophosphoserine inflammatory protection in patients with lupus.
Koelmel JP, Ramos PS, Costa KA, Godri-Pollitt KJ, Kamen DL et al.
Journal of pharmaceutical and biomedical analysis, 2026
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR