Sodium Thioglycolate
AKA “367-51-1, Sodium mercaptoacetate, Mercaptoacetic acid sodium salt, Sodium thioglycollate, Thioglycolate sodium, Mercaptoacetic acid, sodium salt, sodium sulfanylacetate, Sodium 2-mercatoethanoate, Thioglycollic acid
Antioxidant
Ingredient Facts
Sodium thioglycolate
AKA: 367-51-1, Sodium mercaptoacetate, Mercaptoacetic acid sodium salt, Sodium thioglycollate, Thioglycolate sodium, Mercaptoacetic acid, Sodium salt, Sodium sulfanylacetate, Sodium 2-mercatoethanoate, Thioglycollic acid
Antioxidant · Antioxidant · EWG: 4
Synthetic
Antioxidant
Medicated Active
Not Clean
Based on the available data, the CIR Expert Panel concluded that ... Sodium Thioglycolate is safe for use in hair straighteners, permanent waves, tonics, dressings, and so forth, wave sets, other non-coloring hair products, and hair dyes and colors, as described in this safety assessment, at concentrations up to 15.2% (as Thioglycolic Acid). Hairdressers should avoid skin contact and minimize consumer skin exposure. Sodium Thioglycolate in depilatories is safe when formulated to be non-irritating under conditions of recommended use.
Solubility Very soluble (NTP, 1992)
Formula
C2H3NaO2S
Mol. Weight
114.10
CAS #
367-51-1
Form
Powder
State
Thioglycolic acid, sodium salt is a white powder with a slight odor. Used in cold-waving of hair and as a dipilatory.
See origin →
Functions
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Depilatory
Hair Waving Or Straightening
Reducing
Neutralizes Free Radicals
Traditional Use
Developed in the mid-20th century as a chemical reducing agent for hair relaxation and permanent wave treatments. It replaced older, more caustic methods of breaking down hair protein bonds and became the standard ingredient in chemical hair straightening products.
Skin Types
all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
EWG
4
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USApermitted
EUpermitted
JAPANpermitted
CANADApermitted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR