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Squalene
AKA “Spinacene, trans-Squalene, All-trans-Squalene, (6E, 22-hexaene, Spinacen, Nikko Squalane EX, Super Squalene”
Synthetic
Ingredient Facts
Squalene
AKA: Spinacene, Trans-Squalene, All-trans-Squalene, (6E, 22-hexaene, Spinacen, Nikko Squalane EX, Super Squalene
Synthetic · Emollient · EWG: 4
Varies With Manufacturer
Emollient
Skin Conditioner
Plant Oil
Barrier Lipid
Synthetic
Clean
A natural moisturizer that softens and conditions skin while reducing frizz and static in hair. Absorbs easily without feeling heavy or greasy.
Effective at 5.5%
Solubility less than 1 mg/mL at 66 °F (NTP, 1992)
Formula
C30H50
Mol. Weight
410.70
CAS #
111-02-4
See origin →
Functions
Antistatic
Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Reduces Static
Conditions Hair
Refatting
Traditional Use
Unable to provide traditional use description without a valid INCI or common name; this appears to be a CAS number without corresponding ingredient information.
Skin Types
●all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
EWG
4
CIR
Insufficient
Pregnancy
—
CIR Safety Findings
Not a Sensitizer
all-shades-safe
Concentration Guide
1.0%
10.0%
0%14%
Effective Range
CIR reported use: .004-1.2 | .01-10
Regulatory Status
USAunder review
CANADA✔ permitted
Regulatory Agencies
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The Rosehip Ritual
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I-Waken Eye Serum
Indie Lee
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Serum For Days! Trio
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The Resilient Skin Edit
Marie Veronique
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Alpine Rich Cream
Ursa Major
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Supernutrient Firming Facial
Marie Veronique
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Spot Intensive
Marie Veronique
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Replenishing Oil Cleanser
Marie Veronique
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Rejuvenating Night Oil / Extra Healing
Marie Veronique
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Protective Day Oil
Marie Veronique
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Gentle Retinol Night Serum
Marie Veronique
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Control Serum
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COLORFREE ZINC Broad Spectrum Sunscreen | SPF 32
Marie Veronique
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Clarifying Oil
Marie Veronique
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C-Therapy Serum
Marie Veronique
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All Day Age-Delay Emulsion
Marie Veronique
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Advanced Protection Cream
OSEA
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Advanced Protection Cream - 0.25 oz
OSEA
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Bright Start Retinol Alternative Eye Cream
ILIA Beauty
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Credo Beauty
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Back2Brow Pencil
RMS Beauty
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UnCoverup Concealer
RMS Beauty
 →
Squalene Synthase Deficiency.
Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE et al.
, 1993
→
Final Report on the Safety Assessment of Squalane and Squalene
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Squalane and Squalene
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Vitamin C-squalene bioconjugate promotes epidermal thicke...
R Gref, C Deloménie, A Maksimenko, E Gouadon, G Percoco, E Lati + 3 more
Scientific reports, 2020
→
Biological and pharmacological activities of squalene and...
Zih-Rou Huang, Yin-Ku Lin, Jia-You Fang
Molecules (Basel, Switzerland), 2009
→
Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology.
Huang ZR, Lin YK, Fang JY
Molecules (Basel, Switzerland), 2009
→
Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology.
Huang ZR, Lin YK, Fang JY
Molecules (Basel, Switzerland), 2009
→
Biological importance and applications of squalene and sq...
Se-Kwon Kim, Fatih Karadeniz
Advances in food and nutrition research, 2012
→
Biological importance and applications of squalene and sq...
Se-Kwon Kim, Fatih Karadeniz
Advances in food and nutrition research, 2012
→
Biological importance and applications of squalene and sq...
Se-Kwon Kim, Fatih Karadeniz
Advances in food and nutrition research, 2012
→
Biological importance and applications of squalene and squalane.
Kim SK, Karadeniz F
Advances in food and nutrition research, 2012
→
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR