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SUBSTITUTED
Ingredient
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Ingredient Facts
SUBSTITUTED
Ingredient · Skin Conditioning
WHAT IS IT?
Synthetic
Skin Conditioner
Not Clean
SUBSTITUTED is a cosmetic ingredient.
See origin →
WHAT'S IT DO?
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
WHAT'S THE PROOF?
Final Report: Safety Assessment of Dimethicones, Methicone and Substituted-Methicone Polymers as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
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Final Report: Safety Assessment of Linear Phenyl-Substituted Methicones as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
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Growth inhibition of human melanoma tumor cells by the combination of sodium phenylacetate (NaPA) and substituted dextrans and one NaPA-dextran conjug
Gervelas C, Avramoglou T, Crépin M, Jozefonvicz J
Anti-cancer drugs, 2002
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Verified Jun 2026
Data: CosIng