Tetrasodium EDTA
AKA “Sodium edetate, Edetate sodium, EDTA tetrasodium, EDTA sodium, Sodium EDTA, Calsol, EDTA tetrasodium salt, Versene 100, Endrate tetrasodium, Sequestrene”
Ingredient
Ingredient Facts
Tetrasodium edta
AKA: Sodium edetate, Edetate sodium, EDTA tetrasodium, EDTA sodium, Calsol, EDTA tetrasodium salt, Versene 100, Endrate tetrasodium, Sequestrene
Ingredient · Chelating · EWG: 2
Synthetic
Chelating Agent
Clean
Tetrasodium ethylenediaminetetraacetate
Solubility Slightly soluble in ethanol
Formula
C10H12N2Na4O8
Mol. Weight
380.17
CAS #
64-02-8
Form
Powder
State
Dry Powder; Liquid; Other Solid; Dry Powder, Water or Solvent Wet Solid; NKRA; Pellets or Large Crystals; Dry Powder, Liquid
See origin →
Functions
Chelating
Grabs onto metal ions in water that would destabilize the formula. Keeps your product from going bad or changing color.
Removes Metal Ions
Reduces Inflammation
Fights Bacteria
Wound Healing
Binds metal ions
Traditional Use
Synthetic chelating agent developed in the mid-20th century to bind metal ions and prevent oxidation in cosmetics. Created to improve product shelf-life and prevent discoloration.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
EWG
2
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
medical-approval
all-shades-safe
Regulatory Agencies
Final Report on the Safety Assessment of EDTA, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, Disodium EDTA, HEDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA, Trisodium EDTA, and Trisod
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Calcium Disodium EDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
Disodium EDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
Tetrasodium EDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
Trisodium EDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
Calcium Disodium EDTA
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Disodium EDTA
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Tetrasodium EDTA
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Trisodium EDTA
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR