Tocopheryl Acetate
AKA “DL-alpha-Tocopherol acetate, 52225-20-4, all-rac-alpha-Tocopheryl acetate, (+-)-alpha-Tocopherol acetate, WR1WPI7EW8, Alpha-tocopherol acetate, dl-, [2, 5, 7, 8-tetramethyl-2-(4, 8, 12-trimethyltridecyl)-3, 4-dihydrochromen-6-yl] acetate, Tocopheryl Acetate, dl-Alpha, Alpha-tocopheryl acetate, J262.912G
Synthetic
Ingredient Facts
Tocopheryl acetate
AKA: DL-alpha-Tocopherol acetate, 52225-20-4, All-rac-alpha-Tocopheryl acetate, (+-)-alpha-Tocopherol acetate, WR1WPI7EW8, Alpha-tocopherol acetate, Dl-, [2, 5, 7, 8-tetramethyl-2-(4, 8, 12-trimethyltridecyl)-3, 4-dihydrochromen-6-yl] acetate, Dl-Alpha, Alpha-tocopheryl acetate, J262.912G
Synthetic · Antioxidant · EWG: 3
Synthetic
Antioxidant
Skin Conditioner
Synthetic
Not Clean
Vitamin E Acetate is the acetate ester of a fat-soluble vitamin with potent antioxidant properties. Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acid), vitamin E is a generic name for a group of compounds known as tocopherols and tocotrienols (tocols). This agent is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production. Vitamin E also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription. (NCI04)
Effective at 18.0%
Formula
C31H52O3
Mol. Weight
472.70
CAS #
7695-91-2, 58-95-7
Form
Oil
State
Pellets or Large Crystals, Liquid; Pellets or Large Crystals
See origin →
Functions
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Neutralizes free radicals
Prevents moisture loss
Traditional Use
Vitamin E was identified in 1922; the acetate form was synthesized in the 1930s for improved stability in cosmetics. Became widely used in skincare and anti-aging products from the 1970s onward for its antioxidant properties.
Skin Types
all-skin-types
Best For
Sun Damage
Pregnancy & Breastfeeding Safe
Yes
EWG
3
CIR
Safe
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
all-shades-safe
Concentration Guide
1e-08%
36.0%
0%100%
Effective Range
CIR reported use: 0.0000009-5.4 | 0.001-2 | 0.00000001-36 | 0.001-36
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
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Final Report on the Safety Assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilano
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Ascorbyl Tocopheryl Acetate
European Commission
EU Cosmetic Ingredient Database (CosIng)
Tocopheryl Acetate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Uptake and bioconversion of alpha-tocopheryl acetate to a...
E P Norkus, G F Bryce, H N Bhagavan
Photochemistry and photobiology, 1993
Uptake and bioconversion of alpha-tocopheryl acetate to a...
E P Norkus, G F Bryce, H N Bhagavan
Photochemistry and photobiology, 1993
Uptake and bioconversion of alpha-tocopheryl acetate to a...
E P Norkus, G F Bryce, H N Bhagavan
Photochemistry and photobiology, 1993
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR