Tocopheryl Nicotinate
AKA “Vitamin E Nicotinate, 43119-47-7, Renascin, Vitamin E nicotinic acid ester, WI1J5UCY5C, [(2R)-2, 5, 7, 8-tetramethyl-2-[(4R, 8R)-4, 8, 12-trimethyltridecyl]chroman-6-yl] pyridine-3-carboxylate, ((2R)-2, 8-tetramethyl-2-((4R, 12-trimethyltridecyl)chroman-6-yl) pyridine-3-carboxylate, Tocoferil nicotinate, RefChem:898538”
Antioxidant
Ingredient Facts
Tocopheryl nicotinate
AKA: Vitamin E Nicotinate, 43119-47-7, Renascin, Vitamin E nicotinic acid ester, WI1J5UCY5C, [(2R)-2, 5, 7, 8-tetramethyl-2-[(4R, 8R)-4, 8, 12-trimethyltridecyl]chroman-6-yl] pyridine-3-carboxylate, ((2R)-2, 8-tetramethyl-2-((4R, 12-trimethyltridecyl)chroman-6-yl) pyridine-3-carboxylate, Tocoferil nicotinate, RefChem:898538
Antioxidant · Antioxidant · EWG: 1
Synthetic
Antioxidant
Skin Conditioner
Barrier Support
Clean
[2R-[2R*(4R*,8R*)]]-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl nicotinate / [2R*(4R*,8R*)]-(.+-.)-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl nicotinate
Formula
C35H53NO3
Mol. Weight
535.80
CAS #
16676-75-8, 43119-47-7, 51898-34-1, 86362-36-9
Form
Liquid
See origin →
Functions
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Protecting
Helps rebuild and strengthen your skin barrier — the invisible shield that keeps moisture in and irritants out. Essential after over-exfoliating or harsh weather.
Nourishes & Protects
Traditional Use
A synthetic compound combining vitamin E with niacin (vitamin B3) developed in the 20th century. Created to merge two antioxidant vitamins for enhanced skincare benefits.
Skin Types
●all-skin-types
Best For
Redness
Pregnancy & Breastfeeding Safe
Yes
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
Dermal absorption: 1%. Source: CIR Safety Assessment (CIR Seq 667).
Regulatory Agencies
Final Report on the Safety Assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilano
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Tocopheryl Nicotinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
Vitamin E Nicotinate.
Duncan KR, Suzuki YJ
Antioxidants (Basel, Switzerland), 2017
Vitamin E Nicotinate.
Duncan KR, Suzuki YJ
Antioxidants (Basel, Switzerland), 2017
Vitamin E Nicotinate.
Duncan KR, Suzuki YJ
Antioxidants (Basel, Switzerland), 2017
Tocopheryl Nicotinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Toc
Zondlo Fiume M
International journal of toxicology, 2002
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR