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Trehalose
AKA “99-20-7, D-(+)-Trehalose, Mycose, alpha, alpha-trehalose, Ergot sugar, alpha-D-Trehalose, Cabaletta, Mushroom sugar, Natural trehalose”
Synthetic
Ingredient Facts
Trehalose
AKA: 99-20-7, D-(+)-Trehalose, Mycose, Alpha, Alpha-trehalose, Ergot sugar, Alpha-D-Trehalose, Cabaletta, Mushroom sugar, Natural trehalose
Synthetic · Humectant · EWG: 1
Synthetic
Humectant
Skin Conditioner
Synthetic
Clean
Trehalose has been reported in Microchloropsis, Myrothamnus flabellifolia, and other organisms with data available.
Formula
C12H22O11
Mol. Weight
342.30
CAS #
99-20-7
Form
Powder
State
Dry Powder
See origin →
Functions
Humectant
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Draws water to skin
Traditional Use
This CAS number corresponds to glycerol (glycerin). One of the oldest known humectants, used in skincare and medicine for thousands of years as a moisturizer and skin protectant.
Skin Types
●all-skin-types
Best For
General
EWG
1
CIR
Insufficient
Pregnancy
—
CIR Safety Findings
Not a Sensitizer
all-shades-safe
Regulatory Status
USAunder review
CANADA✔ permitted
Regulatory Agencies
Fragrance material review on alpha-amylcinnamyl alcohol.
Bhatia SP, Wellington GA, Cocchiara J, Lalko J, Letizia CS et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2007
→
Fragrance material review on dihydro-alpha-terpineol.
Bhatia SP, McGinty D, Letizia CS, Api AM
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008
→
Trehalose and its applications in the food industry.
Anqi Chen, Hugo Tapia, Julie M Goddard, Patrick A Gibney
Comprehensive reviews in food science and food safety, 2022
→
Trehalose and its applications in the food industry.
Anqi Chen, Hugo Tapia, Julie M Goddard, Patrick A Gibney
Comprehensive reviews in food science and food safety, 2022
→
Trehalose and its applications in the food industry.
Anqi Chen, Hugo Tapia, Julie M Goddard, Patrick A Gibney
Comprehensive reviews in food science and food safety, 2022
→
Final Report on the Safety Assessment of Sodium Alpha-Olefin Sulfonates
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of alpha-Amino Acids as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Sodium alpha-Olefin Sulfonates
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Alpha-Isomethyl Ionone
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Thioctic (Alpha Lipoic) Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Trehalose Undecylenoate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Alpha-Isomethyl Ionone
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Cholecalciferol, 1 Alpha,25 Dihydroxy
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Trehalose
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Alpha-hydroxy acids, including polyhydroxy acids and bionic acids with alpha hydroxyl groups, and their salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Coated Microneedle System for Delivery of Clotrimazole in Deep-Skin Mycoses.
Jadach B, Nowak A, Długaszewska J, Kordyl O, Budnik I et al.
Gels (Basel, Switzerland), 2024
→
[Percutaneous absorption of drug from alpha-olefin oligomer gel bases].
Kaiho F, Hirose C, Shimizu A, Sunada K, Isoyama A et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1992
→
Effects of antioxidant polyphenols on TNF-alpha-related diseases.
Kawaguchi K, Matsumoto T, Kumazawa Y
Current topics in medicinal chemistry, 2011
→
Effects of antioxidant polyphenols on TNF-alpha-related diseases.
Kawaguchi K, Matsumoto T, Kumazawa Y
Current topics in medicinal chemistry, 2011
→
Effects of antioxidant polyphenols on TNF-alpha-related diseases.
Kawaguchi K, Matsumoto T, Kumazawa Y
Current topics in medicinal chemistry, 2011
→
Effects of 1 alpha,25-dihydroxy-vitamin D3 and calcipotriol on organotypic cultures of outer root sheath cells: a potential model to evaluate antipsor
Limat A, Hunziker T, Braathen LR
Archives of dermatological research, 1993
→
Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne.
Liu H, Yu H, Xia J, Liu L, Liu GJ et al.
The Cochrane database of systematic reviews, 2020
→
Uptake and bioconversion of alpha-tocopheryl acetate to a...
E P Norkus, G F Bryce, H N Bhagavan
Photochemistry and photobiology, 1993
→
Uptake and bioconversion of alpha-tocopheryl acetate to a...
E P Norkus, G F Bryce, H N Bhagavan
Photochemistry and photobiology, 1993
→
Uptake and bioconversion of alpha-tocopheryl acetate to a...
E P Norkus, G F Bryce, H N Bhagavan
Photochemistry and photobiology, 1993
→
Safety of alpha-arbutin and beta-arbutin in cosmetic products
Scientific Committee on Consumer Safety (SCCS)
European Commission — SCCS
→
Evaluation of the Synthesis and Skin Penetration Pathway of Folate-Conjugated Polymeric Micelles for the Dermal Delivery of Irinotecan and Alpha-Mango
Sirirak T, Subongkot T
Pharmaceutics, 2025
→
The Efficacy of Topical Cosmetic Containing Alpha-Arbutin...
Pimpa Tantanasrigul, Apinya Sripha, Bunchai Chongmelaxme
Journal of cosmetic dermatology, 2025
→
The Efficacy of Topical Cosmetic Containing Alpha-Arbutin...
Pimpa Tantanasrigul, Apinya Sripha, Bunchai Chongmelaxme
Journal of cosmetic dermatology, 2025
→
The Efficacy of Topical Cosmetic Containing Alpha-Arbutin...
Pimpa Tantanasrigul, Apinya Sripha, Bunchai Chongmelaxme
Journal of cosmetic dermatology, 2025
→
Synthesis and Application of Trehalose Materials.
Vinciguerra D, Gelb MB, Maynard HD
JACS Au, 2022
→
Improvement of Skin Condition Through RXR Alpha-Activating Materials.
Ye S, Lee S, Kang S, Jun SH, Kang NG
Biomolecules, 2025
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR