Tricaprylin
AKA “Trioctanoin, 538-23-8, Tricaprilin, Glycerol trioctanoate, Rato, Glycerol tricaprylate, Caprylin, Trioctanoylglycerol, Glyceryl trioctanoate”
Synthetic
Ingredient Facts
Tricaprylin
AKA: Trioctanoin, 538-23-8, Tricaprilin, Glycerol trioctanoate, Rato, Glycerol tricaprylate, Trioctanoylglycerol, Glyceryl trioctanoate
Synthetic · Skin Conditioning · EWG: 1
Synthetic
Skin Conditioner
Plant Oil
Synthetic
Clean
Trioctanoin is a triglyceride obtained by acylation of the three hydroxy groups of glycerol by octanoic acid. Used as an alternative energy source to glucose for patients with mild to moderate Alzheimer's disease. It has a role as an anticonvulsant and a plant metabolite. It is a triglyceride and an octanoate ester.
Solubility less than 1 mg/mL at 72 °F (NTP, 1992)
Formula
C27H50O6
Mol. Weight
470.70
CAS #
538-23-8
Form
Liquid
State
Tricaprylin is an odorless viscous clear colorless to amber-brown liquid. (NTP, 1992)
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Perfuming
Softens and smooths skin
Traditional Use
A synthetic triglyceride developed as a skin conditioning and emollient agent in modern cosmetics. Created to provide lightweight moisturization similar to natural oils without the odor or spoilage issues.
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
Evaluation of the teratological and dominant lethal potential of N,N-bis-(2-hydroxyethyl)-p-phenylenediamine sulphate in a 6-month feeding study in ra
Burnett CM, Re TA, Loehr RF, Rodriguez SC, Corbett JF
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1986
Final Report on the Safety Assessment of Trilaurin, Triarachidin, Tribehenin, Tricaprin, Tricaprylin, Trierucin, Triheptanoin, Triheptylundecanoin, Triisononanoin, Triisopalmitin, Triisostearin, Trili
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Ceratonia Siliqua (Carob) Gum
European Commission
EU Cosmetic Ingredient Database (CosIng)
Hydrolyzed Ceratonia Siliqua Gum Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
Ceratonia Siliqua (Carob) Gum
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Tricaprylin
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
[Keratoplastic effect of salicyclic acid, sulfur and a tensio-active mixture].
Gloor M, Beier B
Zeitschrift fur Hautkrankheiten, 1984
Keratolytic activity of microemulsions.
Gloor M, Haus G, Keipert S
Skin pharmacology and applied skin physiology, 2003
Keratolytic activity of microemulsions.
Gloor M, Haus G, Keipert S
Skin pharmacology and applied skin physiology, 2003
Keratolytic activity of microemulsions.
Gloor M, Haus G, Keipert S
Skin pharmacology and applied skin physiology, 2003
Keratolytic activity of microemulsions.
Gloor M, Haus G, Keipert S
Skin pharmacology and applied skin physiology, 2003
Keratolytic activity of microemulsions.
Gloor M, Haus G, Keipert S
Skin pharmacology and applied skin physiology, 2003
Keratolytic activity of microemulsions.
Gloor M, Haus G, Keipert S
Skin pharmacology and applied skin physiology, 2003
Keratolytic activity of microemulsions.
Gloor M, Haus G, Keipert S
Skin pharmacology and applied skin physiology, 2003
Keratolytic activity of microemulsions.
Gloor M, Haus G, Keipert S
Skin pharmacology and applied skin physiology, 2003
Keratolytic activity of microemulsions.
Gloor M, Haus G, Keipert S
Skin pharmacology and applied skin physiology, 2003
Keratolytic activity of microemulsions.
Gloor M, Haus G, Keipert S
Skin pharmacology and applied skin physiology, 2003
Keratolytic activity of microemulsions.
Gloor M, Haus G, Keipert S
Skin pharmacology and applied skin physiology, 2003
Imperatorin
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Design of Novel Tricaprylin-Incorporated Multi-Layered Liposomal System for Skin Delivery of Ascorbic Acid with Improved Chemical Stability.
Ho MJ, Park DW, Kang MJ
Pharmaceuticals (Basel, Switzerland), 2023
Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, tr
Johnson W Jr, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2001
Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, tr
Johnson W Jr, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2001
Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, tr
Johnson W Jr, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2001
Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, tr
Johnson W Jr, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2001
Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, tr
Johnson W Jr, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2001
Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, tr
Johnson W Jr, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2001
Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, tr
Johnson W Jr, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2001
Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, tr
Johnson W Jr, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2001
Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, tr
Johnson W Jr, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2001
Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, tr
Johnson W Jr, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2001
Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, tr
Johnson W Jr, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2001
Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, tr
Johnson W Jr, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2001
Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, tr
Johnson W Jr, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2001
Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, tr
Johnson W Jr, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2001
Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, tr
Johnson W Jr, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2001
Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, tr
Johnson W Jr, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2001
Assessing the volatile profile of carob tree (Ceratonia siliqua L.).
Krokou A, Stylianou M, Agapiou A
Environmental science and pollution research international, 2019
An Innovative Formula for Keratosis Pilaris Treatment-A Randomized Controlled Study Based on the "Exfoliation-Dissolution-Repair" Concept.
Liu F, Cheng L, Yang J, Li T, Li J et al.
Journal of cosmetic dermatology, 2026
An Innovative Formula for Keratosis Pilaris Treatment-A Randomized Controlled Study Based on the "Exfoliation-Dissolution-Repair" Concept.
Liu F, Cheng L, Yang J, Li T, Li J et al.
Journal of cosmetic dermatology, 2026
Teratogenic evaluation of 2-nitro-p-phenylenediamine, 4-nitro-o-phenylenediamine, and 2,5-toluenediamine sulfate in the mouse.
Marks TA, Gupta BN, Ledoux TA, Staples RE
Teratology, 1981
Mechanically Robust and Electrically Stable High-Performance Triboelectric Nanogenerator Based on Fluffy-Free EC/Nylon-11 and PTFE/PVDF Nanofibers.
Yang Z, Zhang X, Deng T, Xiang G
ACS applied materials & interfaces, 2023
Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome.
Zoulikha M, Xiao Q, Boafo GF, Sallam MA, Chen Z et al.
Acta pharmaceutica Sinica. B, 2022
Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome.
Zoulikha M, Xiao Q, Boafo GF, Sallam MA, Chen Z et al.
Acta pharmaceutica Sinica. B, 2022
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR