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Triisopropanolamine
AKA “122-20-3, TIPA, TRIS(2-HYDROXYPROPYL)AMINE, Tri-2-propanolamine, Tri-iso-propanolamine, Tris(2-propanol)amine, Tris(2-hydroxy-1-propyl)amine, 2-Propanol, 1, 1', 1''-nitrilotri-, 1''-nitrilotris-”
Ingredient
Ingredient Facts
Triisopropanolamine
AKA: 122-20-3, TIPA, TRIS(2-HYDROXYPROPYL)AMINE, Tri-2-propanolamine, Tri-iso-propanolamine, Tris(2-propanol)amine, Tris(2-hydroxy-1-propyl)amine, 2-Propanol, 1, 1', 1''-nitrilotri-, 1''-nitrilotris-
Ingredient · Buffering · EWG: 7
Synthetic
Not Clean
1,1',1''-Nitrilotripropan-2-ol
Solubility Soluble (NTP, 1992)
Formula
C9H21NO3
Mol. Weight
191.27
CAS #
122-20-3
Form
Liquid
State
Triisopropanolamine is a white solid with slight odor of ammonia. Denser than water.
See origin →
Functions
Buffering
Stabilizes pH
Traditional Use
A synthetic chemical compound developed in the 20th century as a pH buffer and emulsifier in cosmetics. Used to neutralize acids and stabilize formulations.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
EWG
7
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU✔ permitted
JAPAN✔ permitted
CANADA✔ permitted
🧂Conflict of interest.
Extended Re-review Summary: Safety Assessment of Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed Isopropanolamines
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed Isopropanolamine
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Triisopropanolamine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
2-Methyl-1-Phenyl-2-Propanol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Triisopropanolamine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Multiparametric Cranberry (Vaccinium macrocarpon Ait.) Fruit Textural Trait Development for Harvest and Postharvest Evaluation in Representative Culti
Lopez-Moreno H, Phillips M, Diaz-Garcia L, Torres-Meraz M, Jarquin D et al.
Journal of texture studies, 2024
→
The restaurant syndromes.
Settipane GA
New England and regional allergy proceedings, 1987
→
The restaurant syndromes.
Settipane GA
New England and regional allergy proceedings, 1987
→
Verified Jun 2026 · 🧪 = conflict
Data: PubChem · CosIng · EWG · CIR