Tripeptide-1
AKA “glycyl-l-histidyl-l-lysine, 49557-75-7, Prezatide, Liver cell growth factor, Glycyl-histidyl-lysine, Copper(II)ghk, KOLLAREN, ORISTAR GHK, Growth-modulating peptide (human), 39TG2H631E
Skin Conditioning
Ingredient Facts
Tripeptide-1
AKA: Glycyl-l-histidyl-l-lysine, 49557-75-7, Prezatide, Liver cell growth factor, Glycyl-histidyl-lysine, Copper(II)ghk, KOLLAREN, ORISTAR GHK, Growth-modulating peptide (human), 39TG2H631E
Skin Conditioning · Skin Protecting · EWG: 1
Synthetic
Skin Conditioner
Barrier Support
Amino Acid
Clean
Tripeptide-1 is a synthetic peptide containing glycine, histidine, and lysine
Formula
C14H24N6O4
Mol. Weight
340.38
CAS #
-
Form
Powder
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Protecting
Helps rebuild and strengthen your skin barrier — the invisible shield that keeps moisture in and irritants out. Essential after over-exfoliating or harsh weather.
Nourishes & Protects
Traditional Use
A synthetic peptide developed in the late 20th century for anti-aging skincare. Designed to mimic natural skin proteins and stimulate collagen production.
Skin Types
all-skin-types
Best For
Wrinkles
Pregnancy & Breastfeeding Safe
Yes
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
medical-approval
all-shades-safe
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Safety Assessment of Tripeptide-1, Hexapeptide-12 Their Metal Salts and Fatty Acid Derivatives, and Palmitoyl Tetrapeptide-7 as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Bis(Tripeptide-1) Copper Acetate
European Commission
EU Cosmetic Ingredient Database (CosIng)
Copper Tripeptide-1
European Commission
EU Cosmetic Ingredient Database (CosIng)
Manganese Tripeptide-1
European Commission
EU Cosmetic Ingredient Database (CosIng)
Myristoyl Tripeptide-1
European Commission
EU Cosmetic Ingredient Database (CosIng)
Tripeptide-1
European Commission
EU Cosmetic Ingredient Database (CosIng)
Copper Tripeptide-1
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Tripeptide-1
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR