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Trisodium Glycyrrhizate
AKA “Trisodium glycyrrhizinate, Trisodium glycyrrhizin, CCRIS 9136, UNII-5VWB9ZP8JV, 5VWB9ZP8JV, ORISTAR TSG, GLYCYRRHIZINATE, TRISODIUM, TRISODIUM GLYCYRRHIZATE VINYALS, alpha-D-Glucopyranosiduronic acid, (3-beta, 20-beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, trisodium salt”
Skin Conditioning
Ingredient Facts
Trisodium glycyrrhizate
AKA: Trisodium glycyrrhizinate, Trisodium glycyrrhizin, CCRIS 9136, UNII-5VWB9ZP8JV, 5VWB9ZP8JV, ORISTAR TSG, GLYCYRRHIZINATE, TRISODIUM GLYCYRRHIZATE VINYALS, Alpha-D-Glucopyranosiduronic acid, (3-beta, 20-beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, Trisodium salt
Skin Conditioning · Skin Conditioning · EWG: 1
Synthetic
Skin Conditioner
Clean
20beta-Carboxy-11-oxo-30-nor-olean-12-en-3beta-yl-2-O-beta-D-glucopyranuronosyl-alfa-D-glucopyranosiduronic acid, trisodium salt; Trisodium glycyrrhizate
Formula
C42H59Na3O16
Mol. Weight
888.90
CAS #
71277-78-6
Form
Powder
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Brightens uneven skin tone
Evens pigmentation
Quells irritation
Traditional Use
Derived from licorice root (Glycyrrhiza glabra), which has been used in Traditional Chinese Medicine, Ayurveda, and ancient Egyptian medicine for over 3,000 years to soothe inflammation and irritated skin. The trisodium salt form is a modern extraction that concentrates licorice's anti-inflammatory properties.
Skin Types
●all-skin-types
Best For
Redness
Pregnancy & Breastfeeding Safe
Caution
EWG
1
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not an Irritant
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Final Report on the Safety Assessment of EDTA, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, Disodium EDTA, HEDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA, Trisodium EDTA, and Trisod
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report: Safety Assessment of Trisodium Ethylenediamine Disuccinate and Tetrasodium Iminodisuccinate as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Potassium Glycyrrhizinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Trisodium EDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Trisodium Ethylenediamine Disuccinate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Trisodium Fructose Diphosphate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Trisodium Glycyrrhizate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Trisodium HEDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Trisodium Inositol Triphosphate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Trisodium Phosphate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Trisodium EDTA
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Trisodium Ethylenediamine Disuccinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Trisodium Glycyrrhizate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Trisodium HEDTA
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Trisodium Inositol Triphosphate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Trisodium Phosphate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Trisodium Phosphate and Cetylpyridinium Chloride Spraying on Chicken Skin to Reduce Attached Salmonella typhimurium.
Wang WC, Li Y, Slavik MF, Xiong H
Journal of food protection, 1997
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR