undefined 1
undefined 2
Trisodium Phosphate
AKA “7601-54-9, Trisodium orthophosphate, Tromete, Tribasic sodium phosphate, Phosphoric acid trisodium salt, Phosphoric acid, trisodium salt, Oakite, Sodium phosphate, anhydrous, Trinatriumphosphat”
Ingredient
Ingredient Facts
Trisodium phosphate
AKA: 7601-54-9, Trisodium orthophosphate, Tromete, Tribasic sodium phosphate, Phosphoric acid trisodium salt, Phosphoric acid, Trisodium salt, Oakite, Anhydrous, Trinatriumphosphat
Ingredient · Buffering · EWG: 1
Synthetic
Chelating Agent
Clean
The CIR Expert Panel concluded that the following 31 ingredients are safe in the present practices of use and concentration in cosmetics as described in this safety assessment, when formulated to be non-irritating...Trisodium Phosphate...
Effective at 0.28%
Solubility Freely soluble in water. Insoluble in ethanol
Formula
Na3O4P
Mol. Weight
163.94
CAS #
7601-54-9
Form
Powder
State
Sodium phosphate, tribasic appears as a colorless to white crystalline solid. Noncombustible.
See origin →
Functions
Buffering
Chelating
Grabs onto metal ions in water that would destabilize the formula. Keeps your product from going bad or changing color.
Antioxidant
Boosts Collagen
Maintains optimal pH
Binds metal ions
Traditional Use
Developed in the 19th century as an industrial chemical; adopted by the cosmetics industry in the 20th century primarily as a pH buffer and chelating agent rather than for traditional skincare purposes.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
0.006%
0.56%
0%1%
Effective Range
CIR reported use: 0.033-0.4 | 0.006-0.56
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Safety Assessment of Phosphoric Acid and Its Salts as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Calcium Potassium Sodium Phosphate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium Phosphate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Metaphosphoric Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Phosphoric Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Sodium Phosphate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Trisodium Phosphate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Disodium Phosphate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Phosphoric Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Sodium Phosphate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Trisodium Phosphate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug.
Grosios K, Holwell SE, McGown AT, Pettit GR, Bibby MC
British journal of cancer, 1999
→
Trisodium Phosphate and Cetylpyridinium Chloride Spraying on Chicken Skin to Reduce Attached Salmonella typhimurium.
Wang WC, Li Y, Slavik MF, Xiong H
Journal of food protection, 1997
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR