Review
Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S.
J Ashby, H Tinwell, J Plautz, K Twomey, P A Lefevre
ReviewRegulatory toxicology and pharmacology : RTP2001
Research Facts
Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S.
J Ashby, H Tinwell, J Plautz, K Twomey, P A Lefevre
Review · Moderate · 2001
Findings

Tinosorb M-active and Tinosorb S showed no signs of mimicking estrogen or androgen hormones in lab tests or in live animal studies. This is reassuring because some other sunscreen filters have shown hormone-like activity, but these two didn't bind to hormone receptors or trigger estrogenic responses.

Design
Review
Evidence
Moderate
Journal
Regulatory toxicology and pharmacology : RTP
Methodology

Researchers tested both sunscreen ingredients using lab binding assays (to see if they'd stick to hormone receptors) and conducted animal studies to check for hormone-disrupting effects. The study included positive control chemicals that did show expected responses, confirming the test methods worked properly.

Funded By

Funding not disclosed in abstract