Sodium hyaluronate is safe for skincare at concentrations up to 2%. It doesn't cause toxicity, allergic reactions, reproductive harm, or genetic damage in animal studies, and decades of clinical use (mostly through injections) haven't shown significant safety issues.

Researchers reviewed toxicity data across multiple animal species and exposure routes, then analyzed real-world safety records from widespread clinical use of hyaluronic acid and its salt forms.

Funding not disclosed in abstract