Pooled analysis found a modest but statistically significant 22% increased risk of ovarian cancer with perineal talc use (OR 1.22)

This meta-analysis pooled data from 27 epidemiological studies (both case-control and cohort) examining the association between genital talcum powder use and ovarian cancer risk. The pooled odds ratio was 1.22 (95% CI: 1.14–1.31), suggesting a modest but statistically significant increased risk. However, the authors noted potential recall bias in case-control studies and that cohort studies showed weaker associations. This body of evidence contributed to Johnson & Johnson's decision to discontinue talc-based baby powder in 2020 and to broader reformulation efforts in the cosmetics industry.

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