Cohort
Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring.
Lauren E Colbert, Molly B El Alam, Rui Wang, Tatiana Karpinets, David Lo, Erica J Lynn + 39 more
CohortCancer cell2023
Research Facts
Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring.
Lauren E Colbert, Molly B El Alam, Rui Wang, Tatiana Karpinets, David Lo, Erica J Lynn + 39 more
Cohort ยท Moderate ยท 2023
Findings

Researchers found that Lactobacillus iners, a bacterium found in tumors, made cervical cancer cells resistant to chemotherapy and radiation treatment, and was linked to worse patient survival. The same type of lactic acid-producing bacteria showed similar concerning patterns across colorectal, lung, head and neck, and skin cancers. Bottom line: this bacterium fundamentally changes how cancer cells metabolize energy, making treatments less effective.

Design
Cohort
Evidence
Moderate
Journal
Cancer cell
Methodology

Scientists analyzed tumor and gut microbiomes from cervical cancer patients using genetic sequencing and lab cultures, then tested whether isolated Lactobacillus iners bacteria could reduce chemotherapy and radiation effectiveness in cancer cells.

Funded By

Funding not disclosed in abstract