Review
Drug-free gel containing ultra-deformable phospholipid vesicles (TDT 064) as topical therapy for the treatment of pain associated with osteoarthritis: a review of clinical efficacy and safety.
Philip G Conaghan, Johannes W Bijlsma, Werner Kneer, Elspeth Wise, Tore K Kvien, Matthias Rother
ReviewCurrent medical research and opinion2014n=1300
Research Facts
Drug-free gel containing ultra-deformable phospholipid vesicles (TDT 064) as topical therapy for the treatment of pain associated with osteoarthritis: a review of clinical efficacy and safety.
Philip G Conaghan, Johannes W Bijlsma, Werner Kneer, Elspeth Wise, Tore K Kvien, Matthias Rother
Review · Moderate · 2014
Findings

A drug-free gel with phospholipid vesicles (TDT 064) reduced knee osteoarthritis pain and stiffness about as well as the oral drug celecoxib in a study of over 1,300 people over 12 weeks. The tiny phospholipid particles penetrate skin to reach the joint, possibly by lubricating cartilage. Side effects were mild and mostly skin-related.

Design
Review
Sample
n=1300
Evidence
Moderate
Journal
Current medical research and opinion
Methodology

Researchers reviewed preclinical and clinical studies of TDT 064, including randomized phase III trials comparing it to celecoxib (an oral anti-inflammatory) and placebo in patients with knee pain from osteoarthritis.

Funded By

Funding not disclosed in abstract