In-vitro
Butylated Hydroxytoluene (BHT) Protects SH-SY5Y Neuroblastoma Cells from Ferroptotic Cell Death: Insights from In Vitro and In Vivo Studies.
Parisa Faraji, Astrid Borchert, Shahin Ahmadian, Hartmut Kuhn
In-vitroAntioxidants (Basel, Switzerland)2024
Research Facts
Butylated Hydroxytoluene (BHT) Protects SH-SY5Y Neuroblastoma Cells from Ferroptotic Cell Death: Insights from In Vitro and In Vivo Studies.
Parisa Faraji, Astrid Borchert, Shahin Ahmadian, Hartmut Kuhn
In-vitro · Preliminary · 2024
Findings

BHT stopped cell death in lab-grown brain cells when exposed to ferroptosis triggers, working in a dose-dependent way. In rats with Alzheimer's disease, BHT also reduced the expression of genes linked to ferroptosis. This suggests BHT might help protect nerve cells from a specific type of damage, though human evidence doesn't exist yet.

Design
In-vitro
Evidence
Preliminary
Journal
Antioxidants (Basel, Switzerland)
Methodology

Researchers tested BHT on human brain cancer cells in petri dishes, then gave it to rats with an Alzheimer's disease model to see if it prevented ferroptosis-related gene changes.

Funded By

Funding not disclosed in abstract