In-vitro
Butylated Hydroxytoluene (BHT) Protects SH-SY5Y Neuroblastoma Cells from Ferroptotic Cell Death: Insights from In Vitro and In Vivo Studies.
Parisa Faraji, Astrid Borchert, Shahin Ahmadian, Hartmut Kuhn
In-vitroAntioxidants (Basel, Switzerland)2024
Research Facts
Butylated Hydroxytoluene (BHT) Protects SH-SY5Y Neuroblastoma Cells from Ferroptotic Cell Death: Insights from In Vitro and In Vivo Studies.
Parisa Faraji, Astrid Borchert, Shahin Ahmadian, Hartmut Kuhn
In-vitro · Preliminary · 2024
Findings

BHT, a common preservative in cosmetics and oils, protected nerve cells from a type of cell death called ferroptosis in lab tests and in rats with Alzheimer's-like symptoms. It worked by stopping harmful fat oxidation and restoring a key protective enzyme. However, these results are from cells and animals—not human skin or bodies yet.

Design
In-vitro
Evidence
Preliminary
Journal
Antioxidants (Basel, Switzerland)
Methodology

Researchers tested BHT on human nerve cells in a dish, measuring its ability to prevent cell death from two different triggers. They also gave BHT to rats with Alzheimer's disease symptoms and checked if it reduced ferroptosis-related gene activity.

Funded By

Funding not disclosed in abstract