Review
Safety Assessment of PCA (2-Pyrrolidone-5-Carboxylic Acid) and Its Salts as Used in Cosmetics.
Monice M Fiume, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler + 6 more
ReviewInternational journal of toxicology2019
Research Facts
Safety Assessment of PCA (2-Pyrrolidone-5-Carboxylic Acid) and Its Salts as Used in Cosmetics.
Monice M Fiume, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler + 6 more
Review ยท Moderate ยท 2019
Findings

Sodium PCA and related salt forms (calcium, magnesium, potassium) are safe for use in cosmetics at current concentrations, according to the Cosmetic Ingredient Review Expert Panel. The main caveat: these ingredients shouldn't be used in products where N-nitroso compounds could form, as that combination poses a safety concern.

Design
Review
Evidence
Moderate
Journal
International journal of toxicology
Methodology

The expert panel reviewed toxicology data from previous assessments (1999) plus new research on three previously unstudied salt variations of PCA to determine safety at typical usage levels.

Funded By

Funding not disclosed in abstract