Sunscreens with Mexoryl SX provided measurable protection against UV damage at the cellular level, including reduced DNA damage (pyrimidine dimers and p53 buildup), less UV-induced pigmentation, and better preservation of immune function in the skin. The more UVA protection in the formula, the better the pigmentation protection—suggesting this ingredient actually performs as advertised for broad-spectrum defense.

Researchers tested Mexoryl SX-containing sunscreens against UV damage in human volunteers and patients using multiple methods: measuring pigmentation changes, detecting DNA damage markers, assessing immune response suppression, and examining skin tissue changes under the microscope.

Funding not disclosed in abstract