Cohort
Ellagic acid inhibits dihydrotestosterone-induced ferroptosis and promotes hair regeneration by activating the wnt/β-catenin signaling pathway.
Hangjie Fu, Wenxia Li, Jinyuan Liu, Qiehao Tang, Zhiwei Weng, Lijian Zhu + 1 more
CohortJournal of ethnopharmacology2024
Research Facts
Ellagic acid inhibits dihydrotestosterone-induced ferroptosis and promotes hair regeneration by activating the wnt/β-catenin signaling pathway.
Hangjie Fu, Wenxia Li, Jinyuan Liu, Qiehao Tang, Zhiwei Weng, Lijian Zhu + 1 more
Cohort · Moderate · 2024
Findings

Ellagic acid, a compound found in peony extract, helped regrow hair in mice by blocking a type of cell damage (ferroptosis) caused by DHT, the hormone behind male pattern baldness. The ingredient worked by activating a specific cellular pathway called Wnt/β-catenin, and also reduced iron buildup and oxidative stress in hair follicles.

Design
Cohort
Evidence
Moderate
Journal
Journal of ethnopharmacology
Methodology

Researchers tested ellagic acid on mice with DHT-induced hair loss and on human hair follicle cells in a lab. They used multiple lab techniques including microscopy and genetic analysis to track how the compound affected cellular damage and hair regrowth.

Funded By

Funding not disclosed in abstract