Review
The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer.
Ziyu Guo, Danyao Chen, Lei Yao, Yuming Sun, Daishi Li, Jiayuan Le + 4 more
ReviewSignal transduction and targeted therapy2025
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Research Facts
The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer.
Ziyu Guo, Danyao Chen, Lei Yao, Yuming Sun, Daishi Li, Jiayuan Le + 4 more
Review ยท Moderate ยท 2025 ยท Signal transduction and targeted therapy
Findings

This was a review study (not a new experiment) that examined how copper affects cancer cells. Researchers found that copper imbalances exist in various cancers, and a newly discovered process called 'cuproptosis' โ€” essentially copper-triggered cell death โ€” may help suppress tumors and overcome drug resistance. The review suggests that manipulating copper levels could be a promising new approach to cancer treatment.

Design: Review
Evidence: Moderate
Journal: Signal transduction and targeted therapy
Methodology

This is a literature review that synthesized existing research on copper's role in cancer biology, cuproptosis mechanisms, and potential therapeutic applications. The authors analyzed current knowledge rather than conducting original experiments.

Funded By

Funding not disclosed in abstract