Review
Novel nanocapsule of α-lipoic acid reveals pigmentation improvement: α-Lipoic acid stimulates the proliferation and differentiation of keratinocyte in murine skin by topical application.
Yoshiki Kubota, Mina Musashi, Teruaki Nagasawa, Nanako Shimura, Rie Igarashi, Yoko Yamaguchi
ReviewExperimental dermatology2019
Research Facts
Novel nanocapsule of α-lipoic acid reveals pigmentation improvement: α-Lipoic acid stimulates the proliferation and differentiation of keratinocyte in murine skin by topical application.
Yoshiki Kubota, Mina Musashi, Teruaki Nagasawa, Nanako Shimura, Rie Igarashi, Yoko Yamaguchi
Review · Moderate · 2019
Findings

When alpha-lipoic acid was wrapped in tiny nanoparticles (8-15 nanometers) to help it penetrate skin better, it reduced UV-induced dark spots and thickened the epidermis in mouse skin. The improvement came specifically from the alpha-lipoic acid itself, not from the encapsulation materials used.

Design
Review
Evidence
Moderate
Journal
Experimental dermatology
Methodology

Researchers created a nanoencapsulated version of alpha-lipoic acid designed to penetrate skin more effectively, then tested it on mouse skin to see if it could improve UV damage and pigmentation.

Funded By

Funding not disclosed in abstract