Review
Single and mixture toxicity evaluation of avobenzone and homosalate to male zebrafish and H295R cells.
Sujin Lee, Yujin Ka, Bomi Lee, Inhye Lee, Ye Eun Seo, Hyewon Shin + 2 more
ReviewChemosphere2023
Research Facts
Single and mixture toxicity evaluation of avobenzone and homosalate to male zebrafish and H295R cells.
Sujin Lee, Yujin Ka, Bomi Lee, Inhye Lee, Ye Eun Seo, Hyewon Shin + 2 more
Review · Moderate · 2023
Findings

Homosalate, a common sunscreen ingredient, disrupted hormone balance in male fish by lowering testosterone and raising estrogen levels—effects that got worse when combined with avobenzone, another popular UV filter. The chemical appeared to interfere with the body's steroid hormone production system. Researchers note that long-term exposure effects in humans still need investigation.

Design
Review
Evidence
Moderate
Journal
Chemosphere
Methodology

Researchers exposed male zebrafish and human hormone-producing cells to homosalate and avobenzone—alone and in combination—then measured changes in testosterone, estrogen, hormone-related genes, and liver health.

Funded By

Funding not disclosed in abstract