Lab studies show GHK peptide can boost collagen production and reduce wrinkles, but here's the catch: most versions used in actual products haven't been tested on real human skin. The researchers found that GHK struggles to penetrate skin deeply enough to work—it's too water-soluble and breaks down easily—which means the anti-wrinkle claims may not translate from the lab to your face.

This was a literature review that examined existing research on GHK peptides, focusing on their effectiveness for wrinkles and whether they can actually penetrate skin to reach where they need to work.

Funding not disclosed in abstract