Review
The Skin Barrier and Moisturization: Function, Disruption, and Mechanisms of Repair.
Jeffrey Rajkumar, Neha Chandan, Peter Lio, Vivian Shi
ReviewSkin pharmacology and physiology2023
Research Facts
The Skin Barrier and Moisturization: Function, Disruption, and Mechanisms of Repair.
Jeffrey Rajkumar, Neha Chandan, Peter Lio, Vivian Shi
Review · Moderate · 2023
Findings

This review shows that moisturizers work on four different levels of your skin barrier — physical (sealing in water), chemical (maintaining healthy pH and ceramide production), microbiologic (supporting good bacteria), and immunologic (reducing allergen entry). The research confirms that regular moisturizing actually improves water retention and barrier function across all these layers, which matters especially if you have conditions like eczema or sensitive skin.

Design
Review
Evidence
Moderate
Journal
Skin pharmacology and physiology
Methodology

This wasn't an experiment — it's a research review that analyzed existing studies on how skin barriers work and how moisturizers repair them. The authors looked at the science behind different moisturizer types (occlusives, humectants, emollients) and their effects on each barrier layer.

Funded By

Funding not disclosed in abstract