When injected into the skin, low molecular weight hyaluronic acid combined with amino acids boosted collagen production, increased blood vessel formation, and thickened the epidermis in 20 women over 3 months. However, ultrasound measurements showed no statistically significant change in overall skin thickness—meaning the microscopic improvements didn't translate to measurable thickness gains that imaging could detect.

Researchers gave 20 women (ages 35-64) mesotherapy injections with hyaluronic acid fragments and amino acids, then compared skin biopsies and ultrasound scans taken before treatment and 3 months after.

Funding not disclosed in abstract