Phytosphingosine reduced multiple inflammatory markers in skin cells, including nitric oxide, prostaglandin E2, and several pro-inflammatory cytokines (IL-6, IL-8, IL-10). It worked by blocking two major inflammatory signaling pathways in cells (NF-κB and MAPK), suggesting it could help calm skin conditions triggered by immune stress.

Researchers treated immune cells and skin cells with phytosphingosine, then measured inflammatory molecules and traced which cellular pathways were affected using molecular biology techniques.

Funding not disclosed in abstract