Phytosphingosine (PHS) reduced multiple inflammatory markers in skin cells, including IL-6, IL-8, and nitric oxide production. It works by blocking two major inflammatory pathways (NF-κB and MAPK) that trigger skin inflammation—think of it as turning down the volume on your skin's inflammatory response rather than muting it completely.

Researchers exposed human skin cells and immune cells to inflammatory triggers, then treated them with PHS to measure whether inflammatory molecules decreased and which cellular pathways were affected.

Funding not disclosed in abstract